在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human E3 ubiquitin-protein ligase TRIM17 (TRIM17)

  • 中文名稱:
    人TRIM17重組蛋白
  • 貨號:
    CSB-YP897559HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TRIM17重組蛋白
  • 貨號:
    CSB-EP897559HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TRIM17重組蛋白
  • 貨號:
    CSB-EP897559HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TRIM17重組蛋白
  • 貨號:
    CSB-BP897559HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TRIM17重組蛋白
  • 貨號:
    CSB-MP897559HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TRIM17
  • Uniprot No.:
  • 別名:
    E3 ubiquitin-protein ligase TRIM17; RBCC; RING finger protein 16; RING finger protein terf; RNF16; TERF; Testis RING finger protein; TRI17_HUMAN; TRIM 17; Trim17; Tripartite motif containing 17; Tripartite motif containing protein 17; Tripartite motif protein 17; Tripartite motif-containing protein 17
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-477
  • 氨基酸序列
    MEAVELARKL QEEATCSICL DYFTDPVMTT CGHNFCRACI QLSWEKARGK KGRRKRKGSF PCPECREMSP QRNLLPNRLL TKVAEMAQQH PGLQKQDLCQ EHHEPLKLFC QKDQSPICVV CRESREHRLH RVLPAEEAVQ GYKLKLEEDM EYLREQITRT GNLQAREEQS LAEWQGKVKE RRERIVLEFE KMNLYLVEEE QRLLQALETE EEETASRLRE SVACLDRQGH SLELLLLQLE ERSTQGPLQM LQDMKEPLSR KNNVSVQCPE VAPPTRPRTV CRVPGQIEVL RGFLEDVVPD ATSAYPYLLL YESRQRRYLG SSPEGSGFCS KDRFVAYPCA VGQTAFSSGR HYWEVGMNIT GDALWALGVC RDNVSRKDRV PKCPENGFWV VQLSKGTKYL STFSALTPVM LMEPPSHMGI FLDFEAGEVS FYSVSDGSHL HTYSQATFPG PLQPFFCLGA PKSGQMVIST VTMWVKG
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1. Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells. Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1.
  • 基因功能參考文獻:
    1. TRIM17 promoted the removal of midbodies, remnants of the cell division machinery that are known autophagy targets. PMID: 27562068
    2. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis PMID: 25215946
    3. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein. PMID: 19358823
  • 亞細胞定位:
    Cytoplasm. Lysosome.
  • 蛋白家族:
    TRIM/RBCC family
  • 組織特異性:
    Almost exclusively in the testis.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13430

    OMIM: 606123

    KEGG: hsa:51127

    STRING: 9606.ENSP00000295033

    UniGene: Hs.121748



主站蜘蛛池模板: 亚洲区欧美区综合区自拍区| 97色偷偷色噜噜男人的天堂| 久久综合伊人中文字幕| 五十路熟女一区二区三区| 国产日韩精品中文字无码| 成人欧美一区二区三区黑人| 精品久久久久久无码中文字幕一区 | 亚洲色无码中文字幕在线| 亚洲精品中文字幕| 人妻丰满熟妇av无码区免| 99久无码中文字幕一本久道| 中文av岛国无码免费播放| 免费无码黄十八禁网站在线观看| 日韩精品成人一区二区三区| 中文字幕无码av波多野吉衣| 亚洲另类无码专区国内精品| 四十如虎的丰满熟妇啪啪| 东京热无码国产精品| 国产av熟女一区二区三区| 无尺码精品产品视频| 成年无码av片在线免缓冲| 熟妇人妻激情偷爽文| 色窝窝无码一区二区三区色欲| 国产精品久久国产三级国| 色天天天综合色天天| 亚洲中文字幕无码中文| 三级做爰高清视频| 成年男女免费视频网站| 午夜时刻免费入口| 台湾无码av一区二区三区| 国产一卡二卡四卡无卡免费| 中文字幕网伦射乱中文| 久久99国产精一区二区三区| 中文字幕在线亚洲二区| 色欲aⅴ 无码| 绝顶丰满少妇av无码| 人妻无码中文字幕一区二区三区| 国产成人无码视频网站在线观看| 成在线人视频免费视频| 一性一交一口添一摸视频| 少妇人妻上班偷人精品视频|