在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TRIM17 Antibody, FITC conjugated

  • 中文名稱:
    TRIM17兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA897559LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) TRIM17 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    TRIM17
  • 別名:
    E3 ubiquitin-protein ligase TRIM17 antibody; RBCC antibody; RING finger protein 16 antibody; RING finger protein terf antibody; RNF16 antibody; TERF antibody; Testis RING finger protein antibody; TRI17_HUMAN antibody; TRIM 17 antibody; Trim17 antibody; Tripartite motif containing 17 antibody; Tripartite motif containing protein 17 antibody; Tripartite motif protein 17 antibody; Tripartite motif-containing protein 17 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase TRIM17 protein (1-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1. Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells. Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1.
  • 基因功能參考文獻:
    1. TRIM17 promoted the removal of midbodies, remnants of the cell division machinery that are known autophagy targets. PMID: 27562068
    2. NFATc3 interacted in a SUMO-dependent manner with Trim17, an E3 ubiquitin ligase necessary for neuronal apoptosis PMID: 25215946
    3. terf interacts with TRIM44;TRIM44 inhibited ubiquitination of terf, and thus stabilized the protein. PMID: 19358823
  • 亞細胞定位:
    Cytoplasm. Lysosome.
  • 蛋白家族:
    TRIM/RBCC family
  • 組織特異性:
    Almost exclusively in the testis.
  • 數據庫鏈接:

    HGNC: 13430

    OMIM: 606123

    KEGG: hsa:51127

    STRING: 9606.ENSP00000295033

    UniGene: Hs.121748



主站蜘蛛池模板: 99re6在线视频精品免费| 久久精品国产免费播| 精品综合久久久久久98| 色欲av伊人久久大香线蕉影院| 无码国产精品一区二区免费vr| 偷窥国产亚洲免费视频| 国产超级va在线观看视频| 久久国产精品无码一区二区三区| 丰满爆乳无码一区二区三区| 2020国产精品永久在线| 欧美亚洲熟妇一区二区三区| 少妇爆乳无码专区| 亚洲国产精品成人一区二区在线| 国内精品久久久久影院蜜芽| 亚洲欧美中文字幕高清在线| 97精品国产手机| 国产成人精品亚洲777人妖| 老熟妇仑乱一区二区视頻| 无码av免费永久免费永久专区| 四虎永久在线精品免费无码| 日韩欧美群交p片內射中文| 国产午夜成人免费看片| 久久夜色撩人精品国产小说| 欧美亚洲另类自拍丝袜| 宅男噜噜噜66网站在线观看| 久久99国产精一区二区三区| 日本少妇xxx做受| 欧美人与动牲交免费观看| 四虎精品成人免费视频| av无码久久久久不卡蜜桃| 国产成人无码a区在线观看视频app| 亚洲一区二区三区小说| 亚欧成a人无码精品va片| 制服丝袜有码中文字幕在线| 国产香蕉尹人在线观看视频 | 国产美女视频免费观看的网站| 老熟妇hd小伙子另类| 午夜dj在线观看免费视频| 狠狠色噜噜狠狠狠狠av不卡| 国产欧美一区二区精品仙草咪| 欧美 日韩 国产 亚洲 色|