在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Centrosomal protein of 135 kDa (CEP135), partial

  • 中文名稱:
    Recombinant Human Centrosomal protein of 135 kDa(CEP135) ,partial
  • 貨號(hào):
    CSB-YP721063HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Centrosomal protein of 135 kDa(CEP135) ,partial
  • 貨號(hào):
    CSB-EP721063HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Centrosomal protein of 135 kDa(CEP135) ,partial
  • 貨號(hào):
    CSB-EP721063HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Centrosomal protein of 135 kDa(CEP135) ,partial
  • 貨號(hào):
    CSB-BP721063HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Centrosomal protein of 135 kDa(CEP135) ,partial
  • 貨號(hào):
    CSB-MP721063HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    centrosomal protein 135 kDa; centrosomal protein 135kDa; Centrosomal protein 4; Centrosomal protein of 135 kDa; centrosome protein 4; centrosome protein cep135; Cep135; CEP4; CP135_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
  • 基因功能參考文獻(xiàn):
    1. CEP135 segment 96-108 is a major microtubule-binding site. PMID: 27477386
    2. identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly PMID: 26657937
    3. Authors suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication. PMID: 26412126
    4. These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility PMID: 25086031
    5. Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
    6. A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family. PMID: 22521416
    7. CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Microcephaly 8, primary, autosomal recessive (MCPH8)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
  • 蛋白家族:
    CEP135/TSGA10 family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 29086

    OMIM: 611423

    KEGG: hsa:9662

    STRING: 9606.ENSP00000257287

    UniGene: Hs.518767



主站蜘蛛池模板: 国产精成人品日日拍夜夜| 亚洲中文字幕在线无码一区二区| 97超碰国产精品无码分类| 麻豆精品久久久久久中文字幕无码| 午夜视频在线瓜伦| 无码一区二区三区免费| 国产漂亮白嫩美女在线观看| 成人网站www污污污网站| 中文无码乱人伦中文视频在线| 久久天天躁夜夜躁狠狠躁2022| 亚洲精品无码久久毛片| 国产午夜福利在线观看视频_| 性欧美熟妇videofreesex| 亚洲国产精品一区第二页| 国产精品69人妻无码久久| 国产乱码二卡3卡四卡| 凹凸国产熟女精品视频app| 成人看的污污超级黄网站免费| 麻豆人妻无码性色av专区| 极品新婚夜少妇真紧| 亚洲精品成人无限看| 国产 高清 无码 在线播放| 国产精品99久久久久久宅男小说| 少妇被躁爽到高潮无码久久 | 国产又粗又硬又大爽黄老大爷视频| 波多野结衣 黑人| 欧美 日产 国产在线观看| 伊人久久亚洲综合影院首页| 人妻无码久久精品| 2020国产欧洲精品网站| 日韩在线看片免费人成视频播放| 人妻少妇精品中文字幕av蜜桃| 88久久精品无码一区二区毛片 | 国产亚洲精品无码成人| 蜜臀av国产一区二区三区| 久久www成人免费直播| 久久人妻av一区二区软件| 久久人人爽人人爽人人片dvd| 亚洲 综合 自拍 精品 在线| 国产热の有码热の无码视频| 欧美黑人粗大xxxxbbbb|