在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CEP135 Antibody

CEP135 Antibody

  • 中文名稱：
    CEP135兔多克隆抗體
  • 貨號：
    CSB-PA080046
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO cells using CEP135 Polyclonal Antibody
    • Western blot analysis of mouse-lung mouse-heart 293T lysis using CEP135 antibody.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    centrosomal protein 135 kDa antibody; centrosomal protein 135kDa antibody; Centrosomal protein 4 antibody; Centrosomal protein of 135 kDa antibody; centrosome protein 4 antibody; centrosome protein cep135 antibody; Cep135 antibody; CEP4 antibody; CP135_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CEP135.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
  • 基因功能參考文獻：
    1. CEP135 segment 96-108 is a major microtubule-binding site. PMID: 27477386
    2. identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly PMID: 26657937
    3. Authors suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication. PMID: 26412126
    4. These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility PMID: 25086031
    5. Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
    6. A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family. PMID: 22521416
    7. CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

    顯示更多

    收起更多

  • 相關疾病：
    Microcephaly 8, primary, autosomal recessive (MCPH8)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
  • 蛋白家族：
    CEP135/TSGA10 family
  • 數據庫鏈接：

    HGNC: 29086

    OMIM: 611423

    KEGG: hsa:9662

    STRING: 9606.ENSP00000257287

    UniGene: Hs.518767



主站蜘蛛池模板： 日本免费人成视频播放| 啪啪无码人妻丰满熟妇| 久久精品女人天堂av免费观看| 国产精品欧美亚洲韩国日本久久 | 亚洲人成网77777色在线播放| 国产亚洲精品久久yy5099| 亚洲精品无码久久久久av老牛| 国产性色播播毛片| 久久天天躁夜夜躁狠狠85麻豆 | 国产精品xxx在线| 亚洲成h人av无码动漫无遮挡| 特黄做受又粗又长又大又硬| 天堂在线www资源| 色噜噜av男人的天堂| 国产欧美熟妇另类久久久| 国产亚洲精品久久久久动漫| 久久99精品久久久久久久不卡| 久久99热狠狠色精品一区| 人妻无码一区二区不卡无码av| 四虎亚洲精品无码| 精品国产日韩亚洲一区| 久久国产福利国产秒拍| 国产精品爽爽久久久久久竹菊| 成熟女人特级毛片www免费| 蜜臀avwww国产天堂| 草草影院发布页| 欧美日韩无套内射另类| 国产亚洲曝欧美曝妖精品| 色婷婷香蕉在线一区二区| 人人妻人人妻人人片av| 精品国产福利在线视频| 大香伊人久久精品一区二区| 国产av寂寞骚妇| 中文字幕人妻被公上司喝醉在线| 亚洲精品av网站在线观看| 野花社区在线观看视频| 狠狠色婷婷久久综合频道日韩 | 日本无遮挡真人祼交视频| 波多野结av在线无码中文 | 1000部啪啪未满十八勿入| 琪琪电影午夜理论片八戒八戒|