在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CEP135 Antibody

CEP135 Antibody

  • 中文名稱：
    CEP135兔多克隆抗體
  • 貨號：
    CSB-PA868990
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COLO cells, using CEP135 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CEP135 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human CEP135.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner.
  • 基因功能參考文獻：
    1. CEP135 segment 96-108 is a major microtubule-binding site. PMID: 27477386
    2. identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly PMID: 26657937
    3. Authors suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication. PMID: 26412126
    4. These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility PMID: 25086031
    5. Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. PMID: 23511974
    6. A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family. PMID: 22521416
    7. CEP135 acts as a platform protein for C-NAP1 at the centriole. PMID: 18851962

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Microcephaly 8, primary, autosomal recessive (MCPH8)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
  • 蛋白家族：
    CEP135/TSGA10 family
  • 數據庫鏈接：

    HGNC: 29086

    OMIM: 611423

    KEGG: hsa:9662

    STRING: 9606.ENSP00000257287

    UniGene: Hs.518767



主站蜘蛛池模板： 欧美大片aaaaa免费观看| 久久人人玩人妻潮喷内射人人| 极品尤物一区二区三区| 国产成人精品午夜福利| 无码人妻丰满熟妇啪啪7774| 四虎国产精品永久入口| 69成人免费视频无码专区| 欧洲丰满大乳人妻无码欧美| 英语老师丝袜娇喘好爽视频| 色妞www精品视频| 久久精品国产99国产精品亚洲 | 人人妻人人澡人人爽精品欧美| 特级做a爰片毛片免费69| 欧美顶级metart裸体全部自慰| 久久视频这里有精品33| 欧美成人一卡二卡三卡四卡| 中国美女牲交视频| 日韩av高清在线看片| 含紧一点h边做边走动免费视频 | ww国产内射精品后入国产| 女人被狂躁c到高潮喷水电影| 亚洲精品无码久久毛片| 综合 欧美 小说 另类 图| 伊人久久大香线蕉无码| 亚洲熟妇av日韩熟妇在线| 欧美乱强伦xxxxx高潮| 精品一卡2卡3卡4卡新区在线| 女人高潮抽搐喷液30分钟视频| 久久99精品久久久久久秒播| 成人精品一区日本无码网站| 天天躁日日躁狠狠躁人妻| 久久国产av影片| 青青草97国产精品免费观看| 无码午夜成人1000部免费视频| 被窝的午夜无码福利专区| 精品乱人伦一区二区三区| 久久久www免费人成精品| av无码国产在线观看岛国| 日韩欧美亚洲中文乱码| 亚洲a∨无码一区二区三区| 精品免费久久久久久久|