在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Carboxypeptidase D (CPD), partial

In Stock
  • 中文名稱:
    Recombinant Human Carboxypeptidase D(CPD),partial
  • 貨號:
    CSB-EP005885HU1
  • 規(guī)格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    CPD
  • Uniprot No.:
  • 別名:
    Carboxypeptidase D; CBPD_HUMAN; Cpd; gp180 ; Metallocarboxypeptidase D
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    15.8 kDa
  • 表達(dá)區(qū)域:
    383-461aa
  • 氨基酸序列
    GVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. prolactin induction of VEGF-C and Runx2 was inhibited partly by Carboxypeptidase-D inhibitors, implicating nitric oxide , produced by PRL-regulated Carboxypeptidase-D, in breast cancer progression PMID: 28364216
    2. Carboxypeptidase-D (CPD) overexpression coincides with high-grade lung cancer and the CPD overexpression could reverse the inhibitory effects of miR-214 PMID: 27494742
    3. The human carboxypeptidase D transthyretin-like domain forms amyloid under physiological conditions. PMID: 25294878
    4. Prolactin and R1881, acting through Stat5 and androgen receptor, act cooperatively to stimulate CPD gene transcription in breast cancer cells. PMID: 24433040
    5. CPD immunostaining and testosterone/prolactin-stimulated CPD expression were higher in prostate cancer than benign tissues/cells. Elevated CPD increased NO production, which was abolished when both androgen and prolactin receptors were inhibited. PMID: 24615730
    6. Carboxypeptidase D (CPD) is frequently upregulated in hepatocellular carcinoma; targeting CPD inhibits hepatocellular carcinoma cell proliferation through induction of G1 cell-cycle arrest and apoptosis. PMID: 23589395
    7. Either high glucose or insulin (with low glucose) up-regulates beta-cell CPD (but not CPE). PMID: 21628999
    8. Palmitoylation of carboxypeptidase D has a role in intracellular trafficking PMID: 12643288
    9. The isolation and characterization of CPD from several haematopoietic tumour cells are reported. PMID: 15918796
    10. First report to demonstrate carboxypeptidase D as part of the transforming growth factor (TGF)-beta pathway as a TGF-beta target gene implicated in the pathogenesis of lupus erythematosus. PMID: 17641957
    11. prolactin or E2 up-regulated CPD mRNA and protein expression in MCF-7 breast cancer cells promoting their survival PMID: 18535109
    12. CPD releases C-terminal Arg from peptides to provide the precursor substrate for inducible nitric oxide synthase, which enhances nitric oxide synthesis in macrophages. PMID: 11306718

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Peptidase M14 family
  • 組織特異性:
    Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2301

    OMIM: 603102

    KEGG: hsa:1362

    STRING: 9606.ENSP00000225719

    UniGene: Hs.446079



主站蜘蛛池模板: 国产无遮挡裸体免费视频在线观看| 亚洲第一无码av无码专区| 国产精品一区在线观看你懂的 | 日日摸日日碰夜夜爽亚洲综合| 狠狠色噜噜狠狠狠狠五月婷 | 亚洲精品国产精品乱码不卡√| 无码人妻精一区二区三区| 2018国产精华国产精品| 污污又黄又爽免费的网站| 久久亚洲精品人成综合网| 亚洲高清毛片一区二区 | 无码少妇一区二区三区芒果| 成年女人永久免费看片| 国模雨珍浓密毛大尺度150p| 成人天堂婷婷青青视频在线观看| 乱人伦xxxx国语对白| 国产日韩在线视看高清视频手机| 亚洲午夜福利在线视频| 成人欧美一区二区三区黑人 | 国产精品午夜福利麻豆| 亚洲色欲色欲综合网站| 国产一区二区内射最近更新| 欧美xxxxx高潮喷水麻豆| 制服 丝袜 亚洲 中文 综合| 黑人巨大av在线播放无码| 妓院一钑片免看黄大片| 日韩丰满少妇无吗视频激情内射| 亚洲综合熟女久久久40p| 亚洲国产精品无码久久| 免费国产黄网站在线观看| 欧牲交a欧美牲交aⅴ| 四虎永久在线精品免费无码| 欧美寡妇xxxx黑人猛交| 女人的精水喷出来视频| 成年无码av片在线免缓冲| 国内老熟妇乱子伦视频| 免费无码毛片一区二三区| 色婷婷我要去我去也| 亚洲国产精品无码久久sm| 熟妇人妻va精品中文字幕| 成人乱人伦视频在线观看|