在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Carboxypeptidase D (CPD), partial

In Stock
  • 貨號:
    CSB-MP005885HU1
  • 規格:
    ¥3960
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • The purity of CPD was greater than 95% as determined by SEC-HPLC
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC.
  • 基因名:
    CPD
  • Uniprot No.:
  • 別名:
    Metallocarboxypeptidase Dgp180
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    37.3 kDa
  • 表達區域:
    383-461aa
  • 氨基酸序列
    GVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal hFc1-Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 基因功能參考文獻:
    1. prolactin induction of VEGF-C and Runx2 was inhibited partly by Carboxypeptidase-D inhibitors, implicating nitric oxide , produced by PRL-regulated Carboxypeptidase-D, in breast cancer progression PMID: 28364216
    2. Carboxypeptidase-D (CPD) overexpression coincides with high-grade lung cancer and the CPD overexpression could reverse the inhibitory effects of miR-214 PMID: 27494742
    3. The human carboxypeptidase D transthyretin-like domain forms amyloid under physiological conditions. PMID: 25294878
    4. Prolactin and R1881, acting through Stat5 and androgen receptor, act cooperatively to stimulate CPD gene transcription in breast cancer cells. PMID: 24433040
    5. CPD immunostaining and testosterone/prolactin-stimulated CPD expression were higher in prostate cancer than benign tissues/cells. Elevated CPD increased NO production, which was abolished when both androgen and prolactin receptors were inhibited. PMID: 24615730
    6. Carboxypeptidase D (CPD) is frequently upregulated in hepatocellular carcinoma; targeting CPD inhibits hepatocellular carcinoma cell proliferation through induction of G1 cell-cycle arrest and apoptosis. PMID: 23589395
    7. Either high glucose or insulin (with low glucose) up-regulates beta-cell CPD (but not CPE). PMID: 21628999
    8. Palmitoylation of carboxypeptidase D has a role in intracellular trafficking PMID: 12643288
    9. The isolation and characterization of CPD from several haematopoietic tumour cells are reported. PMID: 15918796
    10. First report to demonstrate carboxypeptidase D as part of the transforming growth factor (TGF)-beta pathway as a TGF-beta target gene implicated in the pathogenesis of lupus erythematosus. PMID: 17641957
    11. prolactin or E2 up-regulated CPD mRNA and protein expression in MCF-7 breast cancer cells promoting their survival PMID: 18535109
    12. CPD releases C-terminal Arg from peptides to provide the precursor substrate for inducible nitric oxide synthase, which enhances nitric oxide synthesis in macrophages. PMID: 11306718

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Peptidase M14 family
  • 組織特異性:
    Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines.
  • 數據庫鏈接:

    HGNC: 2301

    OMIM: 603102

    KEGG: hsa:1362

    STRING: 9606.ENSP00000225719

    UniGene: Hs.446079



主站蜘蛛池模板: 久99视频精品免费观看福利| 国产精品永久免费| 人妻少妇邻居少妇好多水在线| 日韩高清成片免费视频| 国产啪视频1000部免费| 毛片免费视频观看| 一本色综合网久久| 国精品午夜福利视频| 99热在线精品国产观看| 午夜精品久久久久久久| 国产喷水福利在线视频| 日本成本人三级在线观看| 欧美真人性做爰一二区| 亚洲日韩国产成网在线观看| 中文在线а天堂| 日99久9在线 | 免费| 肥臀熟女一区二区三区| 成年女人色毛片| 国产成人92精品午夜福利| 久久不见久久见免费视频观看 | 一出一进一爽一粗一大视频免费的| 国产免费无遮挡吸乳视频在线观看| 熟妇人妻无乱码中文字幕| 国产妇女馒头高清泬20p多毛| 亚洲成a人片77777国产| 中文人妻熟妇乱又伦精品| 东京热人妻丝袜av无码| 日本免费大黄在线观看| 日本丰满妇人成熟免费中文字幕 | 国产日韩欧美亚洲精品中字| 99久久国产成人免费网站| 欧美极品少妇无套实战| 夜夜爽一区二区三区精品| 欧美中文字幕无线码视频| 久久99国产精品久久| 特级无码毛片免费视频| 狠人干练合综合网| 女人被狂躁高潮啊的视频在线看| 日本一区二区在线播放| 国产亚洲精品a在线| 亚洲欧美不卡高清在线观看|