在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-FANCG (Ser383) Antibody

  • 中文名稱:
    磷酸化-FANCG (Ser383)兔多克隆抗體
  • 貨號:
    CSB-PA972302
  • 規(guī)格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from K562 cells, using FANCG (Phospho-Ser383) antibody. The lane on the right is treated with the synthesized peptide.
    • Western blot analysis of extracts from cos-7 cells (Lane 2), using FANCG (Phospho-Ser383) Antibody. The lane on the left is treated with synthesized peptide
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FANCG Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FANCG
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Peptide sequence around phosphorylation site of serine 383 (R-F-S(p)-P-P) derived from Human FANCG.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • 基因功能參考文獻:
    1. LOH may predominantly indicate copy number gains in FANCF and losses in FANCG and BRIP1. Integration of copy number data and gene expression proved difficult as the available sample sets did not overlap. PMID: 28440438
    2. studied the impact of mutations on the function and structure of FANCG PMID: 28024295
    3. a systems biology approach for elucidating the therapeutic potential of curcumin against FA and leukemia is investigated by analyzing the computational molecular interactions of curcumin ligand with FANC G of FA and seven other key disease targets of leukemia PMID: 27608133
    4. Patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with Fanconi anemia of heterogeneous genotype. PMID: 25477267
    5. founder haplotype analysis of FANCG for the Korean Fanconi anemia population PMID: 25703136
    6. A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex. PMID: 25132264
    7. Three novel single base pair deletions, resulting in frameshift mutations (c.247delA, c.179delT and c.899delT) were identified in patients with Fanconi anaemia PMID: 24300640
    8. Areca nut extracts-induced miR-23a was correlated with a reduced FANCG expression and DSB repair, which might contribute to ANE-associated human malignancies. PMID: 21750350
    9. Study of the molecular evolution of FA genes using database search methods such as PSI-BLAST suggested that FANCG may contain a known domain, and that this protein is a member of the family of tetratricopeptide repeat-containing proteins. PMID: 12432219
    10. There is remarkably lage sequence variation in FANCG gene mutations and polymorphisms across ethnic and racial backgrounds found in the International Fanconi Anemia Registry they include IVS8-2A>G, IVS11+1G>c, 1794_1803del10, and IVS3+1G>C. PMID: 12552564
    11. FANCG was able to mediate interaction between FANCA and FANCF, as well as between monomers of FANCA PMID: 12649160
    12. FANCG is required for efficient homologous recombination-mediated repair of at least some types of DNA double-strand breaks PMID: 12861027
    13. FANCG interacts directly with BRCA2. PMID: 12915460
    14. A unique Fanconi-anemia-causing mutation, FANCG splice-site mutation IVS4+3A>G, showed exon 4 skipping. PMID: 15059067
    15. Primary fibroblasts from patients with Fanconi anemia with reduced FANCG expression show no signs of telomere dysfunction. PMID: 15319283
    16. FANCG, in addition to stabilising the FA core complex, may have a role in building multiprotein complexes that facilitate homologous recombination repair. PMID: 16621732
    17. Four human FANCG polymorphic variants show normal biological function. PMID: 17010390

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Fanconi anemia complementation group G (FANCG)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
  • 組織特異性:
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3588

    OMIM: 602956

    KEGG: hsa:2189

    STRING: 9606.ENSP00000367910

    UniGene: Hs.591084



主站蜘蛛池模板: 成人精品视频在线观看不卡| av无码人妻一区二区三区牛牛| 18禁裸体女免费观看| 欧美乱码卡一卡二卡三新区| 日本在线视频www鲁啊鲁| 一边摸一边抽搐一进一出视频| 精品国产成人av在线| 99久久婷婷国产综合精品 | 麻豆久久久9性大片| 日韩精品无码中文字幕一区二区 | 亚洲一卡一卡二新区无人区| 免费看成人午夜福利专区| 国产免费福利在线视频| 在线天堂资源www| 久久久精品人妻一区二区三区蜜桃| 亚洲 另类 熟女 字幕| 欧美性生交大片免费看| 国产又色又爽又黄的在线观看视频 | 激情无码人妻又粗又大中国人| 男女免费观看做爰视频在线观看| 不卡无码av一区二区三区| 孕妇怀孕高潮潮喷视频孕妇| 中文字幕 欧美精品 第1页| 国产精品久久久久影院色| 一本大道东京热无码aⅴ| 中文字幕无码人妻少妇免费| 7777精品伊久久久大香线蕉| 任我爽橹在线视频精品583| 少妇无码太爽了不卡视频在线看| 精品一区二区三区免费毛片爱| 激情偷乱人成视频在线观看| 久久人人爽人人爽爽久久小说| 亚洲国产精品ⅴa在线播放| 性色av无码一区二区三区人妻| www国产精品内射| 麻豆自媒体 一区 二区| 欧美视频网站www色| 欧美超级乱婬视频播放| 色偷偷88888欧美精品久久久| 黑色丝袜脚足国产在线看| 欧美成人精品三级网站视频 |