在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-FANCG (S383) Antibody

  • 中文名稱:
    磷酸化-FANCG (S383)兔多克隆抗體
  • 貨號:
    CSB-PA008190
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of K562 cells using Phospho-FANCG (S383) Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    FANCG
  • 別名:
    DNA repair protein XRCC9 antibody; FAG antibody; FANCG antibody; FANCG_HUMAN antibody; Fanconi anaemia complementation group G antibody; Fanconi anemia group G protein antibody; Protein FACG antibody; X ray repair; complementing defective; in Chinese hamster cells 9 antibody; X-ray repair; complementing defective; in Chinese hamster; 9 antibody; XRCC9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Human FANCG around the phosphorylation site of S383.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • 基因功能參考文獻:
    1. LOH may predominantly indicate copy number gains in FANCF and losses in FANCG and BRIP1. Integration of copy number data and gene expression proved difficult as the available sample sets did not overlap. PMID: 28440438
    2. studied the impact of mutations on the function and structure of FANCG PMID: 28024295
    3. a systems biology approach for elucidating the therapeutic potential of curcumin against FA and leukemia is investigated by analyzing the computational molecular interactions of curcumin ligand with FANC G of FA and seven other key disease targets of leukemia PMID: 27608133
    4. Patients, homozygous for the FANCG founder mutation, present with severe cytopenia but progress to bone marrow failure at similar ages to other individuals affected with Fanconi anemia of heterogeneous genotype. PMID: 25477267
    5. founder haplotype analysis of FANCG for the Korean Fanconi anemia population PMID: 25703136
    6. A new role of FANCG in Homologous recombination repair of interstrand crosslinks through K63Ub-mediated interaction with the Rap80-BRCA1 complex. PMID: 25132264
    7. Three novel single base pair deletions, resulting in frameshift mutations (c.247delA, c.179delT and c.899delT) were identified in patients with Fanconi anaemia PMID: 24300640
    8. Areca nut extracts-induced miR-23a was correlated with a reduced FANCG expression and DSB repair, which might contribute to ANE-associated human malignancies. PMID: 21750350
    9. Study of the molecular evolution of FA genes using database search methods such as PSI-BLAST suggested that FANCG may contain a known domain, and that this protein is a member of the family of tetratricopeptide repeat-containing proteins. PMID: 12432219
    10. There is remarkably lage sequence variation in FANCG gene mutations and polymorphisms across ethnic and racial backgrounds found in the International Fanconi Anemia Registry they include IVS8-2A>G, IVS11+1G>c, 1794_1803del10, and IVS3+1G>C. PMID: 12552564
    11. FANCG was able to mediate interaction between FANCA and FANCF, as well as between monomers of FANCA PMID: 12649160
    12. FANCG is required for efficient homologous recombination-mediated repair of at least some types of DNA double-strand breaks PMID: 12861027
    13. FANCG interacts directly with BRCA2. PMID: 12915460
    14. A unique Fanconi-anemia-causing mutation, FANCG splice-site mutation IVS4+3A>G, showed exon 4 skipping. PMID: 15059067
    15. Primary fibroblasts from patients with Fanconi anemia with reduced FANCG expression show no signs of telomere dysfunction. PMID: 15319283
    16. FANCG, in addition to stabilising the FA core complex, may have a role in building multiprotein complexes that facilitate homologous recombination repair. PMID: 16621732
    17. Four human FANCG polymorphic variants show normal biological function. PMID: 17010390

    顯示更多

    收起更多

  • 相關疾病:
    Fanconi anemia complementation group G (FANCG)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.
  • 組織特異性:
    Highly expressed in testis and thymus. Found in lymphoblasts.
  • 數據庫鏈接:

    HGNC: 3588

    OMIM: 602956

    KEGG: hsa:2189

    STRING: 9606.ENSP00000367910

    UniGene: Hs.591084



主站蜘蛛池模板: 亚洲精品tv久久久久久久久久| 欧美牲交视频免费观看| h无码精品3d动漫在线观看 | 免费国精产品自偷自偷免费看| 羞羞色男人的天堂| 日本公与熄乱理在线播放| 国产在线高清亚洲精品二区| 国产三级视频在线播放线观看 | 中文字幕在线无码一区二区三区 | 波多野结衣绝顶大高潮| 亚洲人av在线无码影院观看| 国产亚洲999精品aa片在线爽| 99re在线播放| 天天综合网网欲色| 成全世界免费高清观看| 亚洲乱码无人区卡1卡2卡3| 国产成+人欧美+综合在线观看| 精品人妻av区波多野结衣| 97色伦图片97综合影院| 正在播放重口老熟女露脸| 亚洲国产av无码一区二区三区| 色夜码无码av网站| 日本护士毛茸茸| 少妇邻居内射在线| 国产农村乱人伦精品视频| 亚洲精品成人av观看| 亚洲熟妇无码另类久久久| 中文字幕无码中文字幕有码| 真实国产乱子伦视频| 久久天天躁夜夜躁狠狠躁| 中文字幕无码第1页| 肥臀浪妇太爽了快点再快点| 亚洲一区日韩高清中文字幕亚洲| 国产午夜福利小视频合集| 少妇无码一区二区三区免费| 大肉大捧一进一出视频| 日本无码人妻精品一区二区蜜桃 | 久久超碰精品一夜七次郎| 久久国产免费观看精品a片| av无码免费一区二区三区| 国产精品无码无在线观看|