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STK4

Serine/threonine-protein kinase 4 is a protein in humans that is encoded by STK4 gene. Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

STK4 Antibodies

STK4 for Homo sapiens (Human)

STK4 Proteins

STK4 Proteins for Macaca mulatta (Rhesus macaque)

STK4 Proteins for Papio anubis (Olive baboon)

STK4 Proteins for Colobus guereza (Black-and-white colobus monkey)

STK4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

STK4 Proteins for Aotus nancymaae (Ma's night monkey)

STK4 Proteins for Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)

STK4 Proteins for Lemur catta (Ring-tailed lemur)

STK4 Proteins for Homo sapiens (Human)

STK4 Proteins for Bos taurus (Bovine)

STK4 Proteins for Gallus gallus (Chicken)

STK4 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

STK4 Proteins for Xenopus laevis (African clawed frog)

STK4 Proteins for Squalus acanthias (Spiny dogfish)

STK4 Proteins for Mus musculus (Mouse)



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