在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca mulatta (Rhesus macaque) Serine/threonine-protein kinase 4 (STK4)

  • 中文名稱:
    獼猴STK4重組蛋白
  • 貨號:
    CSB-YP022855MOW
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    獼猴STK4重組蛋白
  • 貨號:
    CSB-EP022855MOW
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    獼猴STK4重組蛋白
  • 貨號:
    CSB-EP022855MOW-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    獼猴STK4重組蛋白
  • 貨號:
    CSB-BP022855MOW
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    獼猴STK4重組蛋白
  • 貨號:
    CSB-MP022855MOW
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    STK4; Serine/threonine-protein kinase 4; EC 2.7.11.1) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit; MST1/N); Serine/threonine-protein kinase 4 18kDa subunit; MST1/C)]
  • 種屬:
    Macaca mulatta (Rhesus macaque)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-487
  • 氨基酸序列
    METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDNFTDFVKQ CLVKSPEQRA TATQLLQHPF VKSAKGVSIL RDLINEAMDV KLKRQESQQR EVDQDDEENS EEDEMDSGTM VRAVGDEMGT VRVASTMTDG ASTMIEHDDT LPSQLGTMVI NTEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKSVPGPLK NSSDWKIPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK KRRQQNF
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 數據庫鏈接:

    KEGG: mcc:717730

    UniGene: Mmu.1760



主站蜘蛛池模板: 中国国语毛片免费观看视频| 久久久久国色av免费观看| 日本一区二区三区免费高清| 50路60路老熟妇啪啪| 久久久精品2020免费观看| 97se亚洲综合自在线| 老子影院无码午夜伦不卡 | 久久人人爽人人人人片| 国产真实夫妇交换视频| 热久久99这里有精品综合久久| 9lporm自拍视频区| 67194熟妇在线观看线路| 日本亲与子乱人妻hd| 久久亚洲精品成人无码网站夜色| 无码少妇一区二区浪潮av| 无码少妇一区二区三区| 少妇特殊按摩高潮惨叫无码| 久久精品人人槡人妻人人玩av| 中文字幕久久精品波多野结百度| 国产精品二区一区二区aⅴ污介绍| 麻豆精品一区二区综合av| 特黄 做受又硬又粗又大视频| 又黄又爽又色的免费网站| 亚洲线精品一区二区三区| 免费体验区试看120秒| 一本大道一卡2卡三卡4卡国产 | 国产黑色丝袜在线看片不卡顿| 久人人爽人人爽人人片av| 久久亚洲精品ab无码播放| av无码午夜福利一区二区三区 | 麻豆国产av丝袜白领传媒| 全免费又大粗又黄又爽少妇片| 久久久久香蕉国产线看观看伊| 亚洲国产精品久久精品成人网站| 少妇与子乱毛片| 性色av极品无码专区亚洲| 婷婷五月深爱综合开心网| 国产手机在线无码播放视频| 少妇极品熟妇人妻无码| 久久亚洲精品情侣| 亚洲成aⅴ人最新无码|