在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MDM2

MDM2,即鼠雙微體基因2蛋白,別名E3泛素蛋白連接酶MDM2、P53結合蛋白。它是一種由MDM2基因編碼的E3泛素連接酶,主要在細胞核質中表達,并與多種蛋白質的泛素化降解途徑相關。MDM2的作用機制之一是介導p53/TP53的泛素化,導致其被蛋白酶體降解,此外,MDM2還參與細胞凋亡過程,通過結合其轉錄激活域抑制p53/TP53和p73/TP73介導的細胞周期阻滯和凋亡 。MDM2在生物學上的意義非常廣泛,它不僅參與調控p53的穩定性和生物功能,還涉及細胞周期、細胞凋亡、DNA損傷響應等多種細胞生理過程。MDM2與p53之間的相互作用形成了一個自動調節的負反饋循環,對維持細胞內環境穩定至關重要。此外,MDM2還通過調控STAT5穩定性來控制T細胞介導的抗腫瘤免疫,這為癌癥免疫治療提供了新的視角和潛在靶點 。

熱銷產品

Recombinant Mouse E3 ubiquitin-protein ligase Mdm2 (Mdm2) (CSB-EP013626MO)

驗證數據

CSB-EP013626MO

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Phospho-MDM2 (S166) Recombinant Monoclonal Antibody (CSB-RA980583A0HU)

驗證數據

CSB-RA980583A0HU

IHC image of CSB-RA980583A0HU diluted at 1:50 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.57% DAB.

CSB-RA980583A0HU

IHC image of CSB-RA980583A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.57% DAB.

CSB-RA980583A0HU

Immunofluorescence staining of HepG2 with CSB-RA980583A0HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 517-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA980583A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA980583A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

MDM2 Antibodies

MDM2 for Homo sapiens (Human)

MDM2 Proteins

MDM2 Proteins for Mus musculus (Mouse)

MDM2 Proteins for Equus caballus (Horse)

MDM2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

MDM2 Proteins for Xenopus laevis (African clawed frog)

MDM2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MDM2 Proteins for Mesocricetus auratus (Golden hamster)

MDM2 Proteins for Felis catus (Cat) (Felis silvestris catus)



主站蜘蛛池模板: 熟女肥臀白浆大屁股一区二区 | 中文字幕亚洲精品乱码| 久久99精品国产99久久6| 亚洲精品久久久久久久蜜桃臀| 国产特级毛片aaaaaaa高清| 亚洲乱亚洲乱妇| 国产a线视频播放| 成 人 网 站 免费 在线| 激情久久av一区av二区av三区| 少妇性l交大片毛多| 电影久久久久久| 萝卜视频高清免费视频日本| 久久丫精品久久丫| 欧美日韩不卡视频合集| 精品久久久无码中文字幕一丶| 久久久久无码精品国产| 国内老熟妇对白hdxxxx| 亚洲精品自偷自拍无码| 无码中文字幕va精品影院| 特级a欧美做爰片三人交| 给我免费的视频在线观看| 超碰免费公开| 97狠狠狠狼鲁亚洲综合网| 好吊妞人成视频在线观看27du| 波多野结衣在线精品视频| 久久精品免费国产大片| 曰批全过程免费视频观看软件潮喷| 亚洲国产av精品一区二区蜜芽| 国产又大又黑又粗免费视频| 性xxxx欧美老妇胖老太269| 女学生14毛片视频片二毛| 亚洲大码熟女在线| 级r片内射在线视频播放| 亚洲午夜久久久久妓女影院| 丝袜高潮流白浆潮喷在线播放 | 高清av熟女一区| 国产又爽又黄又无遮挡的激情视频| 国产超碰人人爽人人做| 午夜精品久久久久久久四虎| 亚洲欧美日韩国产国产a| 激情五月综合色婷婷一区二区|