在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mesocricetus auratus E3 ubiquitin-protein ligase Mdm2 (MDM2)

  • 中文名稱:
    Recombinant Mesocricetus auratus E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號:
    CSB-YP720145MRG
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mesocricetus auratus E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號:
    CSB-EP720145MRG
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mesocricetus auratus E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號:
    CSB-EP720145MRG-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mesocricetus auratus E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號:
    CSB-BP720145MRG
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mesocricetus auratus E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號:
    CSB-MP720145MRG
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    MDM2E3 ubiquitin-protein ligase Mdm2; EC 2.3.2.27; Double minute 2 protein; Oncoprotein Mdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2; Fragment
  • 種屬:
    Mesocricetus auratus (Golden hamster)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-466
  • 氨基酸序列
    STDGAEGTSQ IPASEQETLV RPKPLFLKLL KSVGAQKDTY TMKEIILSWQ YIMTKRLYDE KQQHIVYCSN DLLGDLFGVP SFSVKDHRKI HIMIYRNLVV VSQQETLQSG TSVSESRCQP EGGSEQKDPV QEPQEEKSSS DSVSRPSTSS RRRTISETEE NADELPGDRQ RKRHRSLSFD ESLALCVLRE ICCERSSSSE STDTPSNQDL DDGVSEHSGD WLDQDSVSDQ FSVEFEVESL DSEDYSLSEG GQELSDEDDE VYRVTVYQSG ESDVDSFEGD PEISLADYWK CTSCNEMNPP LPPLCNRCWT LRENWLPEDK EKDRGDASEE AKLEAEGLDV PDGKKATSSD SKESCTEEND DKEIYTSQSQ ESEDYSQPST SSSIVYSSQE DVKEWEKEET ADKEENVESG FSLNAIEPCV ICQGRPKNGC IVHGKTGHLM SCFPCAKKLK KRNKPCPVCR QPIQMI
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis. Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis. Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis.
  • 相關疾病:
    The gene for this protein is overexpressed in some tumors.
  • 亞細胞定位:
    Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus.
  • 蛋白家族:
    MDM2/MDM4 family


主站蜘蛛池模板: 66lu国产在线观看| 免费无码成人av片在线| 久久国产亚洲精品无码| 亚洲日韩久久综合中文字幕| 精品www日韩熟女人妻| 国产在线观看超清无码视频一区二区 | 亚洲毛片无码不卡av在线播放| 国产美女露脸口爆吞精| 国产成人无码a区在线观看视频 | 久久综合给合久久狠狠狠97色| 亚洲日韩av一区二区三区中文| 2019久久视频这里有精品15| 越南女子杂交内射bbwxz| 欧美影院成年免费版| 免费看美女被靠到爽的视频| 国产丰满乱子伦无码专区| 日韩午夜理论片 中文字幕| 熟妇高潮一区二区三区| 夜夜高潮夜夜爽高清完整版1 | 日本va欧美va精品发布| 97久久久久人妻精品区一| 五月综合色婷婷在线观看| 亚洲人精品亚洲人成在线| 欧美极品少妇无套实战| 午夜寂寞少妇aaa片毛片| 少妇高潮太爽了在线视| 97免费人妻在线视频| 一本大道无码人妻精品专区| 中文字字幕在线中文乱码| 国产美女口爆吞精普通话| 国产精品久久久久影院亚瑟| 鲁大师在线视频播放免费观看 | 国产日产欧产精品精品ai| 久久欧美一区二区三区性牲奴| 久久久成人毛片无码| 强奷人妻日本中文字幕| 久久综合九色综合97婷婷| 日韩午夜理论片 中文字幕| 免费国偷自产拍精品视频| 国产精品福利视频一区| 国产av国片精品一区二区|