在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Cat E3 ubiquitin-protein ligase Mdm2 (MDM2)

Recombinant Cat E3 ubiquitin-protein ligase Mdm2 (MDM2)

  • 中文名稱：
    Recombinant Cat E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號：
    CSB-YP770328CA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Cat E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號：
    CSB-EP770328CA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Cat E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號：
    CSB-EP770328CA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Cat E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號：
    CSB-BP770328CA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Cat E3 ubiquitin-protein ligase Mdm2(MDM2)
  • 貨號：
    CSB-MP770328CA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MDM2E3 ubiquitin-protein ligase Mdm2; EC 2.3.2.27; Double minute 2 protein; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2
  • 種屬：
    Felis catus (Cat) (Felis silvestris catus)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-491
  • 氨基酸序列
    MCNTNMSVST DGAVSTSQMP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHEPSDSGT SVSENRCHLE GGSDQKDPVQ ELQEEKPSSS DLVSRPSTSS RRRTISETEE HSDELPGERQ RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYRVTV YQAGESDTDS FEEDPEISLA DYWKCTSCNE MNPPLPPHCN RCWALRENWL PEDKGKDKGK MPEKAKVENS TQVEEGFDVP DCKRTTVNDS RESCAEENDD KITQASQSQE SEDYSQPSTS NSIIHSSQED VKEFEREETQ DKEEIVEPSF PHNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ PIQMIVLTYF P
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis. Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis. Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis.
  • 亞細(xì)胞定位：
    Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus.
  • 蛋白家族：
    MDM2/MDM4 family
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 秋霞午夜成人久久电影网| 久久99精品网久久| 色欲综合一区二区三区| 99久久久国产精品无码免费| 国内精品久久久久影院嫩草| 国产精品国产午夜免费看福利| 亚洲国产成人无码av在线影院| 欧洲人免费视频网站在线| 国产亚洲综合久久系列| 日日碰狠狠躁久久躁综合小说| 国产思思99re99在线观看| 亚洲综合久久精品无码色欲| 牲高潮99爽久久久久777| 国产人妻久久精品二区三区老狼| 国产成a人亚洲精品无码久久网| 乱子轮熟睡1区| 国产成人92精品午夜福利| 久久久97丨国产人妻熟女| 中文无码乱人伦中文视频在线v| 自拍日韩亚洲一区在线| 欧美一区二区三区性视频| 久久www免费人成看片入口| 狠狠色综合tv久久久久久| 久久久综合香蕉尹人综合网| 欧美亚洲色欲色一欲www| 亚洲精品久久婷婷丁香51| 中国浓毛少妇毛茸茸| 久久亚洲中文字幕精品一区| 人妻系列无码专区免费视频| 精品国产制服丝袜高跟| 99re6热视频这里只精品首页 | 天天天天做夜夜夜做| 色欲色香天天天综合无码www| 国产乡下三级全黄三级bd| 国产精品美女久久久浪潮av | 国产精品视频一区二区三区不卡 | 奇米影视777四色狠狠| 乱人伦视频中文字幕| 国产成人无码av一区二区| 日韩综合无码一区二区| 日本看片一二三区高清 |