在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human T-cell antigen CD7 (CD7), partial (Active)

In Stock
  • 貨號:
    CSB-MP004953HU
  • 規格:
    ¥828
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC50 is 1.236-1.773 ng/ml. Biological Activity Assay
    • Activity
      Human CD7 protein hFc and Myc tag (CSB-MP004953HU) captured on COOH chip can bind Human SECTM1 protein hFc tag (CSB-MP819898HU) with an affinity constant of 1.84 nM as detected by LSPR Assay. Biological Activity Assay
    • The purity of CD7 was greater than 95% as determined by SEC-HPLC
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
    Greater than 95% as determined by SEC-HPLC.
  • 內毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC50 is 1.236-1.773 ng/ml.②Human CD7 protein hFc and Myc tag (CSB-MP004953HU) captured on COOH chip can bind Human SECTM1 protein hFc tag (CSB-MP819898HU) with an affinity constant of 1.84 nM as detected by LSPR Assay.
  • 基因名:
  • Uniprot No.:
  • 別名:
    (GP40)(T-cell leukemia antigen)(T-cell surface antigen Leu-9)(TP41)
  • 分子結構:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    46.5 kDa
  • 表達區域:
    26-180aa
  • 氨基酸序列
    AQEVQQSPHCTTVPVGASVNITCSTSGGLRGIYLRQLGPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITMHRLQLSDTGTYTCQAITEVNVYGSGTLVLVTEEQSQGWHRCSDAPPRASALPAPPTGSALPDPQTASALPDPPAASALP
  • 蛋白標簽:
    C-terminal hFc1-Myc-tagged
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    CUSABIO's product CSB-MP004953HU is a recombinant human T-cell antigen CD7. It is produced by the expression of the DNA fragment corresponding to 26-180 AA of the human CD7 protein in mammalian cells. This CD7 protein is fused with a hFc-Myc-tag at the C-terminus. It has been validated to be active through the functional ELISA (bind to the SECTM1, EC50 is 1.236-1.773 ng/ml) and LSPR assay (bind to human SECTM1 protein with an affinity constant of 1.84 nM). The purity of this CD7 protein is greater than 94.5% measured by SDS-PAGE. It contains less endotoxin, <1.0 EU/ug determined by the LAL method. And it is available now.

    CD7 is a cell surface costimulatory molecule expressed on T and NK cells and on cells in the early stages of T-, B-, and myeloid cell differentiation. CD7 binding to its ligand K12/SECTM1 plays a costimulatory role in T-cell activation.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

平均分:
5.0分 - 1 個評價

實驗應用:結合實驗/蛋白間互作

產品評價: 我使用CSB-MP004953HU產品進行ELISA實驗,CD7在 5 μg/ml 可以結合人SECTM1,EC50為1.811-3.372ng/ml,蛋白有較好的結合活性,可以投入我后續研究應用。蛋白重復性好,產品采購方便,價格優惠,后續打算大量采購!

By 許老師

靶點詳情

  • 功能:
    Not yet known.
  • 基因功能參考文獻:
    1. in acute myeloid leukemia patients the association of CD7 positivity and FLT3 positivity was found to be significant PMID: 25679063
    2. Data show that CD7 promotes extramedullary involvement of the B-ALL line Tanoue in an integrin beta2-dependent manner. PMID: 24920488
    3. We showed that the CADM1 versus CD7 plot is capable of discriminating clonally expanding HTLV-I-infected cells in indolent and acute-type T-cell leukemia-lymphomas and in asymptomatic carriers PMID: 24727323
    4. CD7 is present on monocytes and tumor macrophages and its ligand, SECTM1, is frequently expressed in corresponding melanoma tissues PMID: 24157461
    5. SECTM1 secreted from bone marrow stromal cells may interact with CD7 to influence GM-CSF expression in leukemic cells. PMID: 24211252
    6. epigenetic down-regulation of CD7 is associated with acute myeloid leukemia. PMID: 20398252
    7. CD7 loss in aggressive natural killer-cell leukemia; a useful diagnostic marker PMID: 20046078
    8. low expression in T-cell lymphomas due to Twist2-mediated suppression of promoter activity; enhanced by histone deacetylase inhibitors PMID: 19937140
    9. These findings indicate a link between epigenetic modifications and CD7 expression in primitive chronic myeloid leukemia cells. PMID: 20175919
    10. CD7 expression in hematopoitic cells denotes commitment to B-cell and natural killer cells lineages. PMID: 12393702
    11. Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. PMID: 12594831
    12. a novel fusion protein, designated scFvCD7:sFasL is designed to have leukemia-restricted activity. PMID: 16332967
    13. Patients expressing CD7 had significant shorter disease free (DFS) and post-remission survivals (PRS) than patients without CD7 (DFS of 12 months versus 42 months, P=0.005; PRS of 15 months versus 33 months, P=0.013). PMID: 16837044
    14. CD7 antigen notably expresses in lung microvascular endothelial cells (LME) and that it acts as an Fc receptor for IgM in LME cells. PMID: 16990185
    15. HTLV-IInfected cells acquired a profound decrease of intracellular calcium levels in response to ionomycin, timely correlated with decreased CD7 expression PMID: 17287851
    16. differential levels of CD7 identify the progressive stages of lineage commitment in human thymus, initiated from a primitive CD7(-) lympho-myeloid thymic progenitor PMID: 17959857
    17. close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ acute myeloid leukemia suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells PMID: 18343790
    18. The CD7 expression in CD4(+) T cells discriminates between HL and reactive LAD, suggesting that this could be a useful and practical adjunctive tool in the diagnosis of Hodgkin lymphoma. PMID: 18956470
    19. by down-regulating CD7, ATLL cells could have escaped Gal-3-induced apoptosis to run a more aggressive clinical course PMID: 19207946
    20. the galectin-1 glycoprotein receptor CD7 maybe a novel target for GdA on T cells. PMID: 19683346

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 數據庫鏈接:

    HGNC: 1695

    OMIM: 186820

    KEGG: hsa:924

    STRING: 9606.ENSP00000312027

    UniGene: Hs.36972



主站蜘蛛池模板: 国产午精品午夜福利757视频播放| 男人扒开女人内裤强吻桶进去| 欧洲美熟女乱又伦免费视频| 热の综合热の国产热の潮在线| 国产精品无码dvd在线观看| 中文无码vr最新无码av专区| 日韩久久无码免费毛片软件| 国产粉嫩小泬在线观看泬| 无码骚夜夜精品| 国产精品视频| 午夜男女爽爽影院免费视频下载 | 久久人人妻人人爽人人爽| 67194熟妇在线直接进入| 色翁荡熄又大又硬又粗又动态图| 欧美成人一区二区三区在线视频| 国产成人精品视频国产| 思思99热久久精品在线6| 日本中文字幕有码在线视频| 2021年国产精品专区丝袜| 人人爽久久久噜噜噜婷婷| 欧美成人国产精品高潮| 美女国产毛片a区内射| 国产精品一区二区久久乐下载| 护士奶头又大又软又好摸| 亚洲天天做日日做天天谢日日欢| 毛色毛片免费观看| 久久久精品妇女99| 97丨九色丨国产人妻熟女| 夜夜国产亚洲视频香蕉| 亚洲另类激情综合偷自拍图片| 午夜国产亚洲精品一区| 国精产品999国精产品官网| 高潮又爽又无遮挡又免费| 日日摸夜夜摸狠狠摸婷婷| av无码免费永久在线观看| 国产精品久久国产三级国| 亚洲美女高清无水av| 日本免费高清一本视频| 永久黄网站色视频免费| 97久久超碰国产精品最新 | 夜夜高潮夜夜爽夜夜爱爱|