在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Dog E3 ubiquitin-protein ligase Mdm2 (MDM2)

Recombinant Dog E3 ubiquitin-protein ligase Mdm2 (MDM2)

  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-YP013626DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-EP013626DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-EP013626DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-BP013626DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-MP013626DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MDM2E3 ubiquitin-protein ligase Mdm2; EC 2.3.2.27; Double minute 2 protein; Cdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-487
  • 氨基酸序列
    MCNTNMSVST GGAVSTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHEPSDSGT SVSENSCHRE GGSDQKDPVQ ELQEEKPSSS DLISRPSTSS RRRTISETEE HADDLPGERQ RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYRVTV YQAGESDTDS FEEDPEISLA DYWKCTSCNE MNPPLPPHCN RCWALRENWL PEDKGKIPEK ATPENSTQVE EGFDVPDCKK AAASDSRESC AEEIDDKITQ ASHSQESEDY SQPSTSNSII YSSQEDVKEF EREETQDKEE IVESSFPLNA IEPCVICQGR PKNGCIVHGK TGHLMACFTC AKKLKKRNKP CPVCRQPIQM IVLTYFP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis. Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis. Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis.
  • 基因功能參考文獻：
    1. Tumours that exhibited mutation within the MDM2 promoter had amplification of MDM2 protein levels. PMID: 24447820
  • 亞細胞定位：
    Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus.
  • 蛋白家族：
    MDM2/MDM4 family
  • 組織特異性：
    Isoform Mdm2-alpha is present in lymphoid and testicular tissues.
  • 數據庫鏈接：


主站蜘蛛池模板： 色狠狠一区二区三区香蕉| 熟女少妇人妻中文字幕| 亚洲人成色777777老人头| 欧美乱色伦图片区| 欧美国产日韩a在线观看| 亚洲人成无码网www动漫| 日韩精品无码熟人妻视频| 欧美亚洲国产一区二区三区| 亚洲妇熟xxxx妇色黄| 精品亚洲一区二区三区在线播放 | 亚洲国产av无码精品无广告 | 无码动漫性爽xo视频在线观看| 乱色国内精品视频在线| 在线精品自偷自拍无码中文| 无码人妻av一区二区三区蜜臀| 久久无码国产专区精品| av蓝导航精品导航| 日本xxxx片免费观看| 激情综合色五月丁香六月亚洲| 久久免费午夜福利院| 精品国产av一区二区果冻传媒| 久久久精品一区aaa片| 天天射寡妇射| 秋霞鲁丝无码一区二区三区| 亚洲熟妇av日韩熟妇av| 国产人妖视频一区二区| 无翼乌工口肉肉无遮挡无码18| 久久久噜噜噜久久熟女色| 好吊妞人成视频在线观看27du| 躁躁躁日日躁| 成人午夜亚洲精品无码区毛片| 国产亚洲精品第一综合另类| 久久不见久久见免费影院 | 欧美亚洲综合成人a∨在线| 精品无码一区在线观看| 亚洲男人的天堂av手机在线观看| 四虎亚洲中文字幕无码永久| 女人被躁到高潮免费视频| av性色在线乱叫| 国产精品爽爽v在线观看无码| 国产精品老熟女露脸视频|