在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Dog E3 ubiquitin-protein ligase Mdm2 (MDM2)

Recombinant Dog E3 ubiquitin-protein ligase Mdm2 (MDM2)

  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-YP013626DO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-EP013626DO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-EP013626DO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-BP013626DO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    熟悉的犬MDM2重組蛋白
  • 貨號：
    CSB-MP013626DO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MDM2E3 ubiquitin-protein ligase Mdm2; EC 2.3.2.27; Double minute 2 protein; Cdm2; RING-type E3 ubiquitin transferase Mdm2; p53-binding protein Mdm2
  • 種屬：
    Canis familiaris (Dog) (Canis lupus familiaris)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-487
  • 氨基酸序列
    MCNTNMSVST GGAVSTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHEPSDSGT SVSENSCHRE GGSDQKDPVQ ELQEEKPSSS DLISRPSTSS RRRTISETEE HADDLPGERQ RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYRVTV YQAGESDTDS FEEDPEISLA DYWKCTSCNE MNPPLPPHCN RCWALRENWL PEDKGKIPEK ATPENSTQVE EGFDVPDCKK AAASDSRESC AEEIDDKITQ ASHSQESEDY SQPSTSNSII YSSQEDVKEF EREETQDKEE IVESSFPLNA IEPCVICQGR PKNGCIVHGK TGHLMACFTC AKKLKKRNKP CPVCRQPIQM IVLTYFP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation. Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells. Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis. Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis. Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis.
  • 基因功能參考文獻：
    1. Tumours that exhibited mutation within the MDM2 promoter had amplification of MDM2 protein levels. PMID: 24447820
  • 亞細胞定位：
    Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Nucleus.
  • 蛋白家族：
    MDM2/MDM4 family
  • 組織特異性：
    Isoform Mdm2-alpha is present in lymphoid and testicular tissues.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产av成人一区二区三区| 亚洲hdmi高清线| 国产精品熟妇一区二区三区四区 | 正在播放国产乱子伦最新视频 | 国产av国片精品一区二区| 国产v在线最新观看视频| 特级西西人体444www高清大胆| 337p大胆啪啪私拍人体| 亚洲乱亚洲乱妇无码| 国产免费午夜福利在线播放11| 在教室伦流澡到高潮h麻豆| 亚洲午夜久久久精品影院| 狠狠色狠狠色综合| 久久综合色鬼综合色| 中国人妻被两个老外三p| 精品无码久久久久国产app| 亚洲国产中文字幕在线视频综合| 国产成人无码av| 欧美日激情日韩精品嗯| 老熟妇hd小伙子另类| 日欧一片内射va在线影院| 成av免费大片黄在线观看| 中文字幕久久久久人妻中出| 99精品国产在热久久无毒| 亚洲精品久久久久一区二区| 中文精品久久久久国产网址| 国产伦精品一区二区三区| 国产天堂久久天堂av色综合| 日本熟妇厨房xxxxx乱| 午夜不卡av免费| 亚洲欧美综合区丁香五月小说| 日本一区二区a√成人片| 最新在线精品国自产拍视频| 久久国产精品波多野结衣av| 少妇特殊按摩高潮惨叫无码| 少妇扒开双腿让我看个够| 国内精品久久人妻互换 | 先锋影音最新色资源站| 欧美兽交xxxx×视频| 免费观看日本污污ww网站| 奇米影视第四色首页|