在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), partial (Active)

Unavailable
  • 中文名稱:
    人TNFRSF10C重組蛋白
  • 貨號:
    CSB-AP004981HU
  • 規格:
    ¥576
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    The ED50 as determined by its ability to inhibit TRAIL-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TRAIL is typically 450 ng/mL.
  • 基因名:
  • Uniprot No.:
  • 別名:
    TNFRSF10C; DCR1; LIT; TRAILR3; TRID; UNQ321/PRO366; Tumor necrosis factor receptor superfamily member 10C; Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD antigen CD263
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    48.7 kDa
  • 表達區域:
    26-221aa
  • 氨基酸序列
    ATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPA
  • 蛋白標簽:
    C-terminal 6xHis-hFc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
  • 基因功能參考文獻:
    1. High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. PMID: 28420351
    2. DcR1 levels in serum sample which were significantly lower in AMD patients. PMID: 24534820
    3. DcR1 upregulation mediates temozolomide resistance. PMID: 25808868
    4. GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. PMID: 23320456
    5. Primary EOC is associated to a lower TRAIL-R3 expression. PMID: 22555108
    6. Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. PMID: 21281967
    7. Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. PMID: 20799941
    8. Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. PMID: 19936781
    9. analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene PMID: 12417331
    10. cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene PMID: 14623878
    11. Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID: 14999791
    12. The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. PMID: 15538968
    13. Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. PMID: 15921376
    14. tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 PMID: 17690453
    15. p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. PMID: 18345033
    16. TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema PMID: 18511705
    17. Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases PMID: 18590575
    18. inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development PMID: 19035483
    19. Low DCR1 is associated with non-small cell lung cancer. PMID: 19661294

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性:
    Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
  • 數據庫鏈接:

    HGNC: 11906

    OMIM: 603613

    KEGG: hsa:8794

    STRING: 9606.ENSP00000349324

    UniGene: Hs.655801



主站蜘蛛池模板: 51精品国产人成在线观看| 天天鲁在视频在线观看| 亚洲国产精品一区二区动图| 在线|国产精品女主播阳台| 精品日产一卡2卡三卡4卡在线| 天天躁日日躁狠狠躁av麻豆男男 | 熟女人妻av完整一区二区三区| 国产麻豆剧传媒精品国产av| 巨胸美乳无码人妻视频| 又黄又硬又湿又刺激视频免费| 午夜爽爽爽男女免费观看影院| 人人妻人人澡人人爽欧美一区双| 国产精品久久久一区二区| 亚洲精品国产情侣av在线| 国产精品玖玖玖在线| 人妻av中文系列| 两根大肉大捧一进一出好爽视频| 亚洲精品宾馆在线精品酒店 | 中文字幕乱偷无码av先锋| 亚洲色婷婷久久精品av蜜桃| 美女mm131爽爽爽作爱| 久久国产精品老女人| 少妇被爽到高潮喷水久久欧美精品| 国产美女在线精品免费观看 | 边添小泬边狠狠躁视频| 色综合天天综合高清网国产在线| 日本无卡码高清免费v| 精品欧美一区二区三区久久久| 国内精品人妻无码久久久影院| 久久爱www人成狠狠爱综合网| 青青草原精品资源站久久| 五月婷婷开心中文字幕| 青草青草久热国产精品| 久久99久久99久久综合| 亚洲综合另类小说色区一| 国产精品久久久久久久妇| 精品无码久久久久国产电影| 天天摸天天做天天爽水多| 中文幕无线码中文字蜜桃| 寂寞人妻瑜伽被教练日| 欧美日本免费一区二区三区|