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  4. Human tumor necrosis factor-related apoptosis-inducing ligand receptor 3,TRAIL-R3 ELISA Kit

Human tumor necrosis factor-related apoptosis-inducing ligand receptor 3,TRAIL-R3 ELISA Kit

  • 中文名稱：
    人腫瘤壞死因子相關凋亡誘導配體受體3(TRAIL-R3)酶聯免疫試劑盒
  • 貨號：
    CSB-E04748h
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人腫瘤壞死因子相關凋亡誘導配體受體3(TRAIL-R3)酶聯免疫試劑盒（CSB-E04748h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TRAIL-R3含量。TRAIL-R3是重要的靶點。其它屬于腫瘤壞死因子受體超家族成員。研究機制上，它可負調控TRAIL誘導的凋亡信號，在腫瘤細胞逃避凋亡中起作用，對其深入研究有助于了解腫瘤發生發展機制，為腫瘤治療提供新靶點與思路。試劑盒檢測范圍為78 pg/mL-5000 pg/mL，靈敏度為19.5 pg/mL。適用于基礎科研領域，例如探究腫瘤發生機制、細胞凋亡信號通路調控等研究場景，可為體外分析不同生物樣本中TRAIL-R3的蛋白表達水平提供可靠工具。支持科研人員在腫瘤生物學、免疫學等領域開展實驗研究。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    TNFRSF10C ELISA Kit; DCR1 ELISA Kit; LIT ELISA Kit; TRAILR3 ELISA Kit; TRID ELISA Kit; UNQ321/PRO366 ELISA Kit; Tumor necrosis factor receptor superfamily member 10C ELISA Kit; Antagonist decoy receptor for TRAIL/Apo-2L ELISA Kit; Decoy TRAIL receptor without death domain ELISA Kit; Decoy receptor 1 ELISA Kit; DcR1 ELISA Kit; Lymphocyte inhibitor of TRAIL ELISA Kit; TNF-related apoptosis-inducing ligand receptor 3 ELISA Kit; TRAIL receptor 3 ELISA Kit; TRAIL-R3 ELISA Kit; TRAIL receptor without an intracellular domain ELISA Kit; CD antigen CD263 ELISA Kit
  • 縮寫：
    TRAIL-R3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(pg/ml)

    625.668

    628.643

    626.411

    627.471

    624.154

    623.666

    SD

    0.059

    0.048

    0.052

    0.061

    0.055

    0.066

    CV(%)

    5.004

    4.057

    4.407

    5.163

    4.673

    5.611

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human TRAIL R3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    101

    Range %

    88-105

    1:2

    Average %

    104

    Range %

    95-109

    1:4

    Average %

    94

    Range %

    87-98

    1:8

    Average %

    104

    Range %

    99-108

  • 回收率：

    The recovery of human TRAIL R3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range%

    Serum (n=5)

    106

    100-109

    EDTA plasma (n=4)

    101

    95-105

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    5000

    2.652

    2.504

    2.578

    2.408

    2500

    2.326

    2.242

    2.284

    2.114

    1250

    1.736

    1.765

    1.751

    1.581

    625

    1.170

    1.189

    1.180

    1.010

    312

    0.716

    0.698

    0.707

    0.537

    156

    0.515

    0.500

    0.508

    0.338

    78

    0.280

    0.281

    0.281

    0.111

    0

    0.168

    0.172

    0.170

  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
  • 基因功能參考文獻：
    1. High levels of TRAIL-R3 and CCR-2 expression in tumor epithelial cells identified patients with early breast cancer with poor outcomes. PMID: 28420351
    2. DcR1 levels in serum sample which were significantly lower in AMD patients. PMID: 24534820
    3. DcR1 upregulation mediates temozolomide resistance. PMID: 25808868
    4. GATA4 and DcR1 promoter hypermethylation is tumor specific event in glioblastoma but they promoter methylation cannot be considered as a prognostic marker of glioblastoma survival. PMID: 23320456
    5. Primary EOC is associated to a lower TRAIL-R3 expression. PMID: 22555108
    6. Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival. PMID: 21281967
    7. Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores. PMID: 20799941
    8. Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis. PMID: 19936781
    9. analysis of the transcription initiation sites and promoter structure of the TRAIL-R3 gene PMID: 12417331
    10. cloned and characterized a p53 consensus element located within the first intron of the TRAIL-R3 gene PMID: 14623878
    11. Our results demonstrate that DcR1 and DcR2 genes are frequently methylated in various tumor types, and aberrant methylation was the cause for silencing of DcR1 and DcR2 expression. PMID: 14999791
    12. The DcR1 had no death domain and was anchored to the membrane via a glycophosphatidyl inositol tail. PMID: 15538968
    13. Resistance to TRAIL-induced apoptosis in acute myeloid leukemia cells is associated with expression of TRAIL-R3. PMID: 15921376
    14. tryptophol induces apoptosis through DR5 and the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1 PMID: 17690453
    15. p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation. PMID: 18345033
    16. TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema PMID: 18511705
    17. Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases PMID: 18590575
    18. inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development PMID: 19035483
    19. Low DCR1 is associated with non-small cell lung cancer. PMID: 19661294

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 組織特異性：
    Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
  • 數據庫鏈接：

    HGNC: 11906

    OMIM: 603613

    KEGG: hsa:8794

    STRING: 9606.ENSP00000349324

    UniGene: Hs.655801



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