在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Transmembrane 4 L6 family member 20 (TM4SF20)

  • 中文名稱:
    人TM4SF20重組蛋白
  • 貨號:
    CSB-CF709608HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
    TM4SF20
  • Uniprot No.:
  • 別名:
    TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達(dá)區(qū)域:
    1-229
  • 氨基酸序列
    MTCCEGWTSCNGFSLLVLLLLGVVLNAIPLIVSLVEEDQFSQNPISCFEWWFPGIIGAGL MAIPATTMSLTARKRACCNNRTGMFLSSLFSVITVIGALYCMLISIQALLKGPLMCNSPS NSNANCEFSLKNISDIHPESFNLQWFFNDSCAPPTGFNKPTSNDTMASGWRASSFHFDSE ENKHRLIHFSVFLGLLLVGILEVLFGLSQIVIGFLGCLCGVSKRRSQIV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
  • 基因功能參考文獻(xiàn):
    1. Ceramide inverts the membrane orientation of TMS4SF20, creating a form of TM4SF20 that stimulates the cleavage of CREB3L1. PMID: 27499293
    2. TM4SF20 is the first protein shown to undergo Regulated Alternative Translocation in response to ceramide. In the absence of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the ER lumen. This form blocks activation of CREB3L1, a membrane-bound transcription factor. In the presence of ceramide, the membrane topology of TM4SF20 is inverted. The inverted form stimulates CREB3L1 cleavage. PMID: 27499293
    3. TM4SF20 ancestral deletion predisposes carriers to a pediatric disorder of early language delay and cerebral white matter hyperintensities. PMID: 23810381
  • 相關(guān)疾病:
    Specific language impairment 5 (SLI5)
  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    L6 tetraspanin family
  • 組織特異性:
    Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 26230

    OMIM: 615404

    KEGG: hsa:79853

    UniGene: Hs.156652



主站蜘蛛池模板: 国产区精品福利在线社区| 久久久噜噜噜久久熟女色| 亚洲人成黄网站69影院| 国产又大又硬又粗| 国产日韩综合一区二区性色av| 亚洲日本va午夜中文字幕久久| 国产三级视频在线播放线观看| 女女女女女裸体处开bbb| 中年熟妇的大黑p| 国产丝袜无码一区二区视频| 亚洲色欲av无码成人专区| 特级西西人体444www高清大胆| 日韩成人极品在线内射3p蜜臀| 国产成人免费无码av在线播放| 国产成人无码av大片大片在线观看| 老熟妇性老熟妇性色| 国产熟妇高潮叫床视频播放| 在线亚洲精品国产一区麻豆| 亚洲精品第一国产综合国服瑶| 亚洲中文字幕久久精品无码喷水| 国产色在线 | 亚洲| 日本中文字幕人妻不卡dvd| 国产欧美国日产高清| 中文人妻熟女乱又乱精品| 国产精品爽爽久久久久久竹菊 | 亚洲成av人片天堂网| 国产白袜脚足j棉袜在线观看| 亚洲欧美日韩成人综合一区| 久久久精品人妻一区二区三区gv| 亚洲男女一区二区三区| 熟妇人妻中文av无码| 国产精品美女久久久网站动漫| 日本特黄aaaaaa大片| 天天躁日日躁很很很躁| 色婷婷五月综合久久| 人人妻人人爽人人添夜夜欢视频| 日本乱子伦一区二区三区| www国产内插视频| 国产成人亚洲综合无码品善网| 久久午夜无码鲁丝片| 无码高潮少妇毛多水多水免费|