在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TM4SF20 Antibody, Biotin conjugated

TM4SF20 Antibody, Biotin conjugated

  • 中文名稱：
    TM4SF20兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA709608LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TM4SF20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TM4SF20
  • 別名：
    TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transmembrane 4 L6 family member 20 protein (114-184AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
  • 基因功能參考文獻：
    1. Ceramide inverts the membrane orientation of TMS4SF20, creating a form of TM4SF20 that stimulates the cleavage of CREB3L1. PMID: 27499293
    2. TM4SF20 is the first protein shown to undergo Regulated Alternative Translocation in response to ceramide. In the absence of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the ER lumen. This form blocks activation of CREB3L1, a membrane-bound transcription factor. In the presence of ceramide, the membrane topology of TM4SF20 is inverted. The inverted form stimulates CREB3L1 cleavage. PMID: 27499293
    3. TM4SF20 ancestral deletion predisposes carriers to a pediatric disorder of early language delay and cerebral white matter hyperintensities. PMID: 23810381
  • 相關疾病：
    Specific language impairment 5 (SLI5)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    L6 tetraspanin family
  • 組織特異性：
    Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum.
  • 數據庫鏈接：

    HGNC: 26230

    OMIM: 615404

    KEGG: hsa:79853

    UniGene: Hs.156652



主站蜘蛛池模板： 137裸交肉体摄影| 色77久久综合网| 国产欧美熟妇另类久久久| 日韩插啊免费视频在线观看| 欧美亚洲国产手机在线有码| 偷柏自拍亚洲综合在线| 日本熟妇人妻xxxx| 边啃奶头边躁狠狠躁| 国产传媒麻豆剧精品av国产| 亚洲精品字幕在线观看| 偷看农村妇女牲交| 国产精品无码久久综合网| 中文字幕av一区| 97久久国产亚洲精品超碰热| 风韵人妻丰满熟妇老熟女| 亚洲精品av一区在线观看| 伊人久久大香线蕉亚洲五月天| 大陆极品少妇内射aaaaaa| 未满十八18禁止免费无码网站| 国色天香社区视频手机免费| 国产高清在线精品一区下载| 黑人大荫蒂老太大| 午夜性开放午夜性爽爽| 国产超碰人人做人人爱一二区视品| a在线视频v视频| 伊人色综合久久天天五月婷| 日本久久高清一区二区三区毛片 | 久久精品国产99久久久小说| av性色av久久无码ai换脸| 亚洲综合天堂av网站在线观看| 国产精品无码无卡无需播放器| 色一情一乱一乱一区99av| 少妇群交换bd高清国语版| 精品少妇人妻av一区二区| 欧美性猛交xxx嘿人猛交| 久久久国产乱子伦精品| 国产精品久久久久久无毒不卡| 在线亚洲精品国产一区麻豆| av网站的免费观看| 国产人妻777人伦精品hd| 欧美私人情侣网站|