在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TM4SF20 Antibody, Biotin conjugated

TM4SF20 Antibody, Biotin conjugated

  • 中文名稱：
    TM4SF20兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA709608LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TM4SF20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TM4SF20
  • 別名：
    TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transmembrane 4 L6 family member 20 protein (114-184AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
  • 基因功能參考文獻：
    1. Ceramide inverts the membrane orientation of TMS4SF20, creating a form of TM4SF20 that stimulates the cleavage of CREB3L1. PMID: 27499293
    2. TM4SF20 is the first protein shown to undergo Regulated Alternative Translocation in response to ceramide. In the absence of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the ER lumen. This form blocks activation of CREB3L1, a membrane-bound transcription factor. In the presence of ceramide, the membrane topology of TM4SF20 is inverted. The inverted form stimulates CREB3L1 cleavage. PMID: 27499293
    3. TM4SF20 ancestral deletion predisposes carriers to a pediatric disorder of early language delay and cerebral white matter hyperintensities. PMID: 23810381
  • 相關疾病：
    Specific language impairment 5 (SLI5)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    L6 tetraspanin family
  • 組織特異性：
    Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum.
  • 數據庫鏈接：

    HGNC: 26230

    OMIM: 615404

    KEGG: hsa:79853

    UniGene: Hs.156652



主站蜘蛛池模板： 韩国美女视频黄是免费| 日韩精品无码不卡无码| 老色鬼永久精品网站| 国产精品兄妹在线观看麻豆| 国产精品无码a∨精品影院app| 无码三级国产三级在线电影| 久久久久久无码av成人影院| 午夜精品久久久久久毛片| 欧美牲交a欧美在线| 国产一区二区三区四区精华| 国产精品一区二区av交换| 国产精品盗摄!偷窥盗摄| 香蕉久久久久久久av网站| 午夜成人无码片在线观看影院| 久久99九九精品久久久久蜜桃 | 欧美三级午夜理伦三级| 日本肥老妇色xxxxx日本老妇| 交换交换乱杂烩系列yy| 久久高清超碰av热热久久| 成人婷婷网色偷偷亚洲男人的天堂| 色窝窝无码一区二区三区| 色综合视频一区中文字幕| 亚洲精品无码鲁网中文电影| 成人免费区一区二区三区| 色一情一区二| 综合色区国产亚洲另类| 久久无码专区国产精品| 亚洲一区二区观看播放| 中文人妻熟妇乱又伦精品| 国产吃奶在线观看| 99久久国产热无码精品免费| 久久久久99精品成人片牛牛影视| 高潮射精日本韩国在线播放| 天天鲁一鲁摸一摸爽一爽| 99蜜桃在线观看免费视频网站| 亚洲欧美综合精品成人导航 | 亚洲日韩av无码一区二区三区| 国产人妻精品区一区二区三区| 免免费国产aaaaa片| 艳妇乳肉豪妇荡乳av无码福利| 国产精品人妻系列21p|