在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein SERAC1 (SERAC1)

  • 中文名稱:
    人SERAC1重組蛋白
  • 貨號:
    CSB-CF853443HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    SERAC1
  • Uniprot No.:
  • 別名:
    SERAC1; Protein SERAC1; Serine active site-containing protein 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-654
  • 氨基酸序列
    MSLAAYCVICCRRIGTSTSPPKSGTHWRDIRNIIKFTGSLILGGSLFLTYEVLALKKAVT LDTQVVEREKMKSYIYVHTVSLDKGENHGIAWQARKELHKAVRKVLATSAKILRNPFADP FSTVDIEDHECAVWLLLRKSKSDDKTTRLEAVREMSETHHWHDYQYRIIAQACDPKTLIG LARSEESDLRFFLLPPPLPSLKEDSSTEEELRQLLASLPQTELDECIQYFTSLALSESSQ SLAAQKGGLWCFGGNGLPYAESFGEVPSATVEMFCLEAIVKHSEISTHCDKIEANGGLQL LQRLYRLHKDCPKVQRNIMRVIGNMALNEHLHSSIVRSGWVSIMAEAMKSPHIMESSHAA RILANLDRETVQEKYQDGVYVLHPQYRTSQPIKADVLFIHGLMGAAFKTWRQQDSEQAVI EKPMEDEDRYTTCWPKTWLAKDCPALRIISVEYDTSLSDWRARCPMERKSIAFRSNELLR KLRAAGVGDRPVVWISHSMGGLLVKKMLLEASTKPEMSTVINNTRGIIFYSVPHHGSRLA EYSVNIRYLLFPSLEVKELSKDSPALKTLQDDFLEFAKDKNFQVLNFVETLPTYIGSMIK LHVVPVESADLGIGDLIPVDVNHLNICKPKKKDAFLYQRTLQFIREALAKDLEN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway.
  • 基因功能參考文獻:
    1. Two novel SERAC1 mutations were identified in two cases of dystonia, 3-methylglutaconic aciduria and intellectual disability syndrome. PMID: 28778788
    2. mutations in the phosphatidylglycerol remodelling enzyme SERAC1 can cause juvenile-onset complicated hereditary spastic paraplegia (cHSP) clusters PMID: 28916646
    3. Several different SERAC1 variants were identified from individuals with Deafness-Dystonia syndrome. PMID: 29205472
    4. Here we report two new Turkish sibling patients affected with MEGDEL syndrome due to SERAC1 gene mutation. PMID: 27186703
    5. Infantile mitochondrial hepatopathy is a cardinal feature of MEGDEL syndrome (3-methylglutaconic aciduria type IV with sensorineural deafness, encephalopathy and Leigh-like syndrome) caused by novel mutations in SERAC1. PMID: 23918762
    6. During the course of this project a parallel study identified mutations in SERAC1 as the genetic cause of the disease in 15 patients with MEGDEL syndrome, which was compatible with the clinical and biochemical phenotypes of the patient described here. PMID: 23707711
    7. Data identify SERAC1 as a key player in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. PMID: 22683713

    顯示更多

    收起更多

  • 相關疾病:
    3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL)
  • 亞細胞定位:
    Membrane; Single-pass membrane protein. Endoplasmic reticulum. Mitochondrion. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface.
  • 蛋白家族:
    SERAC1 family
  • 組織特異性:
    Widely expressed, with predominant expression in fetal skeletal muscle and adult brain. In the brain, highest levels are found in the frontal and occipital cortices, cerebellum and hippocampus.
  • 數據庫鏈接:

    HGNC: 21061

    OMIM: 614725

    KEGG: hsa:84947

    STRING: 9606.ENSP00000356071

    UniGene: Hs.154706



主站蜘蛛池模板: 妇女性内射冈站hdwww000| 中文字幕精品亚洲无线码一区| 中年熟妇的大黑p| 中文精品久久久久人妻| 欧美国产伦久久久久久久| 国产av一二三无码影片| 四虎影视永久免费观看| 精品视频一区二区三区在线观看| 国产亚洲一卡2卡3卡4卡网站| 国产成人精品s8视频| 国产成人精品无码播放| 无码任你躁久久久久久久| 精品亚洲成a人在线观看青青| 亚洲成aⅴ人片在线观| 欧美日韩视频无码一区二区三| 日韩人妻无码一区二区三区久久99| 辽宁熟女高潮狂叫视频| 无码专区无码专区视频网址| 国产av国片精品| 狠狠爱亚洲五月婷婷av| 先锋影音人妻啪啪va资源网站| 国产一在线精品一区在线观看| 日韩综合夜夜香内射| 日本国产网曝视频在线观看| 超碰成人人人做人人爽| 久久综合伊人77777麻豆| 久久久国产精华液| 18禁黄污无遮挡无码网站| 国产女人乱人伦精品一区二区| 亚洲一区av在线观看| 久久亚洲国产精品亚洲老地址| 青草国产精品久久久久久| 国产精品99无码一区二区| 国产性猛交╳xxx乱大交| 被窝的午夜无码福利专区| 日韩欧美在线综合网另类| 无码高潮少妇毛多水多水免费 | 国产精品无码2021在线观看| 成人亚洲a片v一区二区三区动漫| 久久久www成人免费无遮挡大片| 国产99视频精品免费视看9 |