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  4. Recombinant Sheep Interferon tau-1 (IFNT1)

Recombinant Sheep Interferon tau-1 (IFNT1)

  • 中文名稱：
    綿羊IFNT1重組蛋白
  • 貨號：
    CSB-YP350007SH
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    綿羊IFNT1重組蛋白
  • 貨號：
    CSB-EP350007SH-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    綿羊IFNT1重組蛋白
  • 貨號：
    CSB-BP350007SH
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    綿羊IFNT1重組蛋白
  • 貨號：
    CSB-MP350007SH
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    IFNT1
  • Uniprot No.：
  • 別名：
    IFNT1; OTPInterferon tau-1; IFN-tau-1; Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; TP-1; Trophoblastin
  • 種屬：
    Ovis aries (Sheep)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    24-195
  • 氨基酸序列
    CYLSRKL MLDARENLKL LDRMNRLSPH SCLQDRKDFG LPQEMVEGDQ LQKDQAFPVL YEMLQQSFNL FYTEHSSAAW DTTLLEQLCT GLQQQLDHLD TCRGQVMGEE DSELGNMDPI VTVKKYFQGI YDYLQEKGYS DCAWEIVRVE MMRALTVSTT LQKRLTKMGG DLNSP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
  • 基因功能參考文獻：
    1. These studies provide in vivo evidence that IFNT is a critical regulator of conceptus elongation and that its embryotrophic actions are primarily mediated by paracrine effects on the endometrium. PMID: 25505203
    2. 74 genes were affected by IFNT in a progesterone-dependent manner, and 180 genes were regulated by IFNT in a progesterone-independent manner in endometrium during pregnancy [IFNT interferon tau ] PMID: 16251498
    3. Uterine vein releases IFN-tau, which induces ISG15 and OAS-1 in extrauterine tissues such as the corpus luteum during the time of maternal recognition of pregnancy. PMID: 18063687
  • 亞細胞定位：
    Secreted. Note=Secreted into the uterine lumen.
  • 蛋白家族：
    Alpha/beta interferon family, IFN-alphaII subfamily
  • 組織特異性：
    Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.
  • 數據庫鏈接：

    KEGG: oas:100144750

    UniGene: Oar.17312



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