在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Gremlin-1 (Grem1)

  • 中文名稱:
    大鼠Grem1重組蛋白
  • 貨號:
    CSB-EP009892RAc7
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Grem1; Cktsf1b1; Drm; Gremlin-1; Cysteine knot superfamily 1; BMP antagonist 1; Down-regulated in Mos-transformed cells protein
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    20.2 kDa
  • 表達區域:
    25-184aa
  • 氨基酸序列
    KKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
  • 基因功能參考文獻:
    1. gremlin1 promotes hepatic stellate cell activation and hepatic fibrogenesis through impairment of the balance between transforming growth factor beta and bone morphogenetic protein 7 signaling pathways. PMID: 27863390
    2. The therapeutic mechanism of Danshao Huaxian capsule in hepatic fibrosis may be associated with inhibition of the expression of Gremlin and up-regulation of the expression of BMP-7. PMID: 25356047
    3. GREM1 affects follicle transition in cultured ovaries, but is not normally present in primordial and early-stage developing follicles. PMID: 24614542
    4. Notch pathway gene expression is elevated in diabetic nephropathy, co-incident with Gremlin, and may contribute to the pathogenesis of this dise PMID: 17980714
    5. Gremlin plays a part in the development of pathological phenotypic changes of adult vascular smooth muscle cell. PMID: 18086474
    6. The bone morphogenetic protein antagonist gremlin promotes vascular smooth muscle cell apoptosis. PMID: 19142012

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    DAN family
  • 組織特異性:
    Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver. Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine.
  • 數據庫鏈接:


主站蜘蛛池模板: 西西人体大胆午夜啪啪| 国产毛片久久久久久国产毛片 | 欧美午夜片欧美片在线观看| 综合精品欧美日韩国产在线| 成人国产一区二区精品小说| 欧美性潮喷xxxxx免费视频看| 人妻大战黑人白浆狂泄| 久久久久女人精品毛片| 国产做a爰片久久毛片a片白丝| 国产精品亚洲a∨天堂| 天天天天躁天天爱天天碰2018| 人人妻人人澡人人爽人人精品浪潮| 国产精品爽爽久久久久久竹菊| 国内精品乱码卡一卡2卡麻豆| 影音先锋啪啪av资源网站| 小宝极品内射国产在线| 国产亚洲精品久久777777| 久久人妻无码中文字幕第一| 无码av免费一区二区三区四区| 欧美精品videosbestsex日本| 狠狠噜天天噜日日噜| 尹人香蕉久久99天天拍久女久| 国产女人喷潮视频免费| 国精品99久9在线 | 免费| 国产成人无码a区在线观看视频 | 国产露脸精品产三级国产av| 无码午夜人妻一区二区不卡视频| 无码丰满少妇2在线观看| 无码国产精品一区二区免费式芒果| 欧美孕妇乳喷奶水在线观看| 日本欧美一区二区三区在线播放| 亚洲自偷自拍另类11p| 日日摸日日碰人妻无码老牲| 婷婷色中文字幕综合在线| 国产在线高清亚洲精品二区| 国产午夜理论不卡在线观看| 激情偷乱人伦小说视频在线| 老司机午夜福利视频| 亚洲精品欧美精品日韩精品| 精品国产日韩亚洲一区| 综合 欧美 亚洲日本|