在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Wee1-like protein kinase (Wee1)

  • 中文名稱:
    小鼠Wee1重組蛋白
  • 貨號:
    CSB-YP026084MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Wee1重組蛋白
  • 貨號:
    CSB-EP026084MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Wee1重組蛋白
  • 貨號:
    CSB-BP026084MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Wee1重組蛋白
  • 貨號:
    CSB-MP026084MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Wee1; Wee1-like protein kinase; EC 2.7.10.2; Wee1A kinase
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-646
  • 氨基酸序列
    MSFLSRQQPP PTRRVGAAYS LRQKLIFSPG SDCEEEEEEE EEGSGHSTGE DSAFQEPDSP LPSARSPAEA EAERRRRSPG AEPSSPGELE DDLLLQGGGG GAQAAGGGAE GDSWEEEGFG SSSPVKSPST AYFLSSPFSP VRCGGPGDAS PQGCGAPRAM DDPCSPQPDY PSTPPHKTFR KLRLFDTPHT PKSLLSKARV IDSGSVKLRG SSLFMDTEKS GKREFDTRQT PQVNINPFTP DPVLLHSSGR CRGRKRAYFN DSSEDMEASD YEFEDETRPA KRITITESNM KSRYTTEFHE LEKIGSGEFG SVFKCVKRLD GCIYAIKRSK KPLAGSVDEQ NALREVYAHA VLGQHPHVVR YFSAWAEDDH MLIQNEYCNG GSLADAISEN YRVMSYLTEV ELKDLLLQVG RGLRYIHSMS LVHMDIKPSN IFISRTSIPN AVSEEGDEDD WISNKVMFKI GDLGHVTRIS SPQVEEGDSR FLANEVLQEN YSHLPKADIF ALALTVVCAA GAEPLPRNGE QWHEIRQGRL PRIPQVLSQE VTELLRVMIH PDPERRPSAM ELVKHSVLLS ASRKSAEQLR IELNAEKFKN SLLQKELKKA QMAAKVAAEE RALFTDRMAT RSTTQSNRTS RLIGKKMNRS VSLTIY
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
  • 基因功能參考文獻:
    1. Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting the morphine-induced macrophage apoptosis. PMID: 27253431
    2. Results revealed that WEE1 is indispensable for maintaining genomic stability and it functions as a haploinsufficient tumor suppressor. PMID: 25088202
    3. Wee1 is directly or indirectly involved in the mechanism of the circadian rhythm-dependent changes in docetaxel-induced intestinal damage. PMID: 23892568
    4. The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels. PMID: 21918363
    5. In this study, we found that the chromosomal wee1 gene is also down-regulated by KLF3. PMID: 22115574
    6. The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons. PMID: 20026642
    7. Mammalian Wee1 plays a critical role in maintaining genome integrity and is essential for embryonic survival at the pre-implantation stage of mouse development. PMID: 16810330
    8. expression of wee1 was directly regulated by the molecular components of the circadian clockwork in the regenerating liver PMID: 12934012
    9. transcription repressive activity of TBP-related factor 2 to wee1 promoter needs association with the promoter and TFIIA PMID: 17109819
    10. the suppression of nuclear import of cyclin B1, the induction of Wee1 kinase activity, and the transient nuclear accumulation of p21(CIP1/WAF1) may play important roles in the transient cell cycle delay in response to ionizing radiation PMID: 18425394

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 东北少妇不戴套对白第一次| 中文字幕无线码| 最近最新中文字幕高清免费| 色欲久久综合亚洲精品蜜桃| 国产白袜脚足j棉袜在线观看| 99国产欧美另娄久久久精品| 国产精品女人呻吟在线观看| 午夜精品久久久内射近拍高清| 国产精品久久国产精品99| 曰批全过程免费视频观看软件潮喷 | 色妺妺在线视频| 中文字幕aⅴ在线视频| 国产福利在线永久视频| 免费va人成视频网站全| 中文字幕在线亚洲二区| 国产精品高潮呻吟av久久无吗| 成年女性特黄午夜视频免费看| 少妇裸体性生交| 久久996re热这里有精品| 亚洲日韩色在线影院性色| 亚洲综合av色婷婷| 天天做天天爱天天综合网| 人妻中文无码久热丝袜| 欧美黑人乱大交| 18禁亚洲深夜福利人口| 欧美国产综合欧美视频| 欧美内射rape视频| 无码国产精品久久一区免费| 国产精品午夜小视频观看| 国产精品va在线播放| 中文字幕大看蕉在线观看| 亚洲日本在线在线看片| 亚洲国产成人爱av在线播放| 国产极品白嫩精品| 狼人大香伊蕉国产www亚洲| 8天堂资源在线| 国产熟女一区二区三区四区五区 | av蓝导航精品导航| 精品一区精品二区制服| 亚洲人成无码网站久久99热国产 | 亚洲精品国产av成拍色拍个|