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WEE1

Wee1-like protein kinase is a protein in humans that is encoded by WEE1 gene. Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

WEE1 Antibodies

WEE1 for Homo sapiens (Human)

WEE1 Proteins

WEE1 Proteins for Homo sapiens (Human)

WEE1 Proteins for Mus musculus (Mouse)

WEE1 Proteins for Drosophila melanogaster (Fruit fly)

WEE1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

WEE1 Proteins for Rattus norvegicus (Rat)

WEE1 Proteins for Oryza sativa subsp. japonica (Rice)

WEE1 Proteins for Arabidopsis thaliana (Mouse-ear cress)



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