在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Gamma-secretase subunit APH-1A (Aph1a), partial

Recombinant Mouse Gamma-secretase subunit APH-1A (Aph1a), partial

  • 中文名稱：
    Recombinant Mouse Gamma-secretase subunit APH-1A(Aph1a),partial
  • 貨號：
    CSB-YP806914MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Gamma-secretase subunit APH-1A(Aph1a),partial
  • 貨號：
    CSB-EP806914MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Gamma-secretase subunit APH-1A(Aph1a),partial
  • 貨號：
    CSB-EP806914MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Gamma-secretase subunit APH-1A(Aph1a),partial
  • 貨號：
    CSB-BP806914MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Gamma-secretase subunit APH-1A(Aph1a),partial
  • 貨號：
    CSB-MP806914MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Aph1a; Gamma-secretase subunit APH-1A; APH-1a; Aph-1alpha
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
  • 基因功能參考文獻：
    1. Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase. PMID: 27349870
    2. ficiency of beta-arrestin1 or inhibition of binding of beta-arrestin1 with APH-1 by small peptides reduced Abeta production without affecting Notch processing PMID: 23208420
    3. Pen-2, as well as nicastrin and Aph-1alpha, is dispensable for presenilin endoproteolysis PMID: 22973949
    4. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates PMID: 20145246
    5. presenilin 1 (PS1)-derived fragments, mature nicastrin, APH-1, and PEN-2, associate with cholesterol-rich detergent insoluble membrane (DIM) domains of non-neuronal cells and neurons PMID: 15322084
    6. Our findings establish that APH-1a is the major mammalian APH-1 homolog present in presenilin-dependent gamma-secretase complexes during embryogenesis. PMID: 15634781
    7. Nct has a critical role in the stability and proper intracellular trafficking of other components of the PS1/ gamma-secretase complex but not in maintaining the association of PEN-2, APH-1, and full-length PS1 PMID: 15711015

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein.
  • 蛋白家族：
    APH-1 family
  • 數據庫鏈接：


主站蜘蛛池模板： 伊人久久精品无码二区麻豆| av毛片无码中文字幕不卡| 亚洲大码熟女在线观看| 亚洲欧美日韩综合久久久久久 | 天堂а√在线中文在线新版| 日产日韩亚洲欧美综合下载| 国产一卡2卡3卡4卡国色天香| 又粗又大又黄又爽的免费视频| 波多野结衣av手机在线观看| 亚洲一二三四2021不卡| 人人玩人人添人人澡欧美| 国产av无码专区亚汌a√| 粗大猛烈进出高潮视频免费看| 久久精品2021国产| 欧美黑人又粗又大xxx| 日韩精品射精管理在线观看| 欧美xxxx精品另类| 青青草无码免费一二三区| 亚洲成av人片高潮喷水| 青青草视频在线观看| 国产无遮挡又爽又刺激的视频老师| 欧美成aⅴ人高清怡红院 | 国产精品乱子伦xxxx裸| 亚洲欧洲美洲在线观看| 久久伊人蜜桃av一区二区| 国产午夜三级一区二区三| 久久久久久人妻毛片a片| 欧洲美女黑人粗性暴交| 国产成人久久婷婷精品流白浆| 丰满岳乱妇一区二区三区| 亚洲中文有码字幕日本第一页| 十八禁无码免费网站| 无码丰满熟妇| 亚洲乱码日产精品bd在线看| www一区二区乱码www| 67194熟妇在线观看线路| 海角社区在线视频播放观看| 国产欧美日韩亚洲精品专区| 午夜成人理论无码电影在线播放 | 西西人体大胆午夜啪啪| 国产欧色美视频综合二区|