在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3 (Cnga3), partial

Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3 (Cnga3), partial

  • 中文名稱：
    Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3(Cnga3),partial
  • 貨號：
    CSB-YP888333MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3(Cnga3),partial
  • 貨號：
    CSB-EP888333MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3(Cnga3),partial
  • 貨號：
    CSB-EP888333MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3(Cnga3),partial
  • 貨號：
    CSB-BP888333MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cyclic nucleotide-gated cation channel alpha-3(Cnga3),partial
  • 貨號：
    CSB-MP888333MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cnga3; Cng3; Cyclic nucleotide-gated cation channel alpha-3; Cone photoreceptor cGMP-gated channel subunit alpha; Cyclic nucleotide-gated channel alpha-3; CNG channel alpha-3; CNG-3; CNG3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3.
  • 基因功能參考文獻：
    1. AAV8 with capsid Y-F and T-V mutations may be one of the most effective AAV vectors for long-term treatment in a naturally occurring mouse model of CNGA3 achromatopsia PMID: 29131863
    2. CNGA3 expression restored cone function in in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia. PMID: 25855802
    3. cGMP/protein kinase G signaling suppresses Itpr1 phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice. PMID: 26124274
    4. Homologous to the human disease, CNGA3 deficient mice reveal a loss of cone specific functionality leading to degeneration of affected cone photoreceptors. (review) PMID: 24658860
    5. This work investigated the functional modulation of cone CNG channel by exploring the channel-interacting proteins. PMID: 24664681
    6. The results of this study indicated that cGMP accumulation in photoreceptors can itself exert cytotoxic effect in cones, independently of CNG channel activity and Ca(2+) influx. PMID: 24027293
    7. observed a nuclear translocation of apoptosis-inducing factor (AIF) and endonuclease G in CNGA3(-/-)/Nrl(-/-) and CNGB3(-/-)/Nrl(-/-) retinas, implying a mitochondrial insult in the endoplasmic reticulum stress-activated cell death process PMID: 22493484
    8. Pull-down assays indicated that the binding to organ of Corti CNGA3 was attributable to the EMILIN1 intracellular sequence that follows a predicted transmembrane domain in the C-terminus PMID: 22248097
    9. Cone CNG channel is a heterotetrameric complex likely at a stoichiometry of three CNGA3 and one CNGB3. PMID: 22183405
    10. This study provided evidence that CNGA3 contributes in an inhibitory manner to the central sensitization of pain pathways during inflammatory pain as a target of NO/cGMP signaling. PMID: 21813679
    11. The wild type and mutant CNGA3 were expressed in HEK293 cells, the channel's expression and cellular localization were examined by immunoblotting and immunofluorecences labeling, and activity of the channel was evaluated. PMID: 20238023
    12. our data describe a so far unrecognized role of CNGA3 in modulation of hippocampal plasticity and amygdala-dependent fear memory PMID: 20846178
    13. Data show that visual responses in TKO mice extend beyond the retina to encompass the lateral margins of the lateral geniculate nucleus and components of the visual cortex. PMID: 21124780
    14. CNGA3 was strongly expressed in the Grueneberg ganglion and the expression of CNGA3 was confined to those cells that are responsive to coolness PMID: 20165899
    15. R377W and F488L mutations in the C-terminus of CNGA3 cause the loss of functional activity of the channels PMID: 20088482
    16. The results show that cone bipolar cells in CNGA3(-/-) mice form ectopic synapses with rods. PMID: 16687517
    17. Thus this work provides the first biochemical evidence showing the inter-subunit interaction between CNGA3 and CNGB3 and the presence of heterotetrameric complexes of the native cone CNG channel in retina. PMID: 18665891

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA3 subfamily
  • 組織特異性：
    Prominently expressed in retina.
  • 數據庫鏈接：


主站蜘蛛池模板： 奇米影视777四色狠狠| 亚洲精品成a人在线观看| 国产精品极品美女自在线观看免费| 乱人伦中文视频在线| 大肉大捧一进一出好爽app| 无码精品久久久久久人妻中字| 国产高清不卡免费视频| 国产三级视频在线观看视| 超碰97久久国产精品牛牛| 成人无码www免费视频| 久久亚洲精品ab无码播放| 国产成在线观看免费视频| 亚洲人成线无码7777| 荫道bbwbbb高潮潮喷| 亚洲 自拍 另类小说综合图区| 亚洲欧美成人综合图区| 天天爽夜夜爽人人爽免费| 午夜精品久久久久久久喷水| 亚洲一区 日韩精品 中文字幕| 亚洲高清无码加勒比| 肉体裸交137日本大胆摄影| 日日碰狠狠躁久久躁婷婷| 亚洲综合在线另类色区奇米| 国产精品主播一区二区三区| 国产在线精品一品二区| 国产精品激情av久久久青桔| 成人区精品一区二区婷婷| 久久人妻国产精品| 人妻av无码专区久久| 天天躁日日躁狠狠躁欧美老妇| 性欧美性另类巨大| 亚洲精品人成网线在播放va| 国产青榴视频在线观看| 亚洲欧美成人一区二区三区| 国产青草视频在线观看| 亚洲一卡一卡二新区迎热烈讨论| 末成年女av片一区二区| 国内精品伊人久久久久影院麻豆| 国产精品国产三级国av麻豆| 亚洲欧洲无码av一区二区三区 | 亚洲综合精品成人|