在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Zona pellucida sperm-binding protein 3 (ZP3), partial

  • 中文名稱:
    人ZP3重組蛋白
  • 貨號:
    CSB-EP027121HU1
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    ZP3
  • Uniprot No.:
  • 別名:
    HUMZP3; Processed zona pellucida sperm-binding protein 3; Sperm receptor; zona pellucida glycoprotein 3 (sperm receptor); Zona pellucida glycoprotein 3; zona pellucida glycoprotein 3A (sperm receptor); Zona pellucida glycoprotein ZP3; Zona pellucida protein C; Zona pellucida sperm binding protein 3 precursor; Zp-3; ZP3 372; ZP3 424; ZP3 474; ZP3; ZP3_HUMAN; ZP3A; ZP3A/ZP3B; ZP3B; ZPC
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    63.0kDa
  • 表達區域:
    23-346aa
  • 氨基酸序列
    QPLWLLQGGASHPETSVQPVLVECQEATLMVMVSKDLFGTGKLIRAADLTLGPEACEPLVSMDTEDVVRFEVGLHECGNSMQVTDDALVYSTFLLHDPRPVGNLSIVRTNRAEIPIECRYPRQGNVSSQAILPTWLPFRTTVFSEEKLTFSLRLMEENWNAEKRSPTFHLGDAAHLQAEIHTGSHVPLRLFVDHCVATPTPDQNASPYHTIVDFHGCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRNMIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQPHVMSQWSRS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
  • 基因功能參考文獻:
    1. The zona pellucida-3 (ZP3) protein plays a pivotal role in oocyte and gamete development. PMID: 30341457
    2. The oocyte ZP3 expression was the main predictor of the fertilization capacity. PMID: 28204536
    3. Missense Mutation in ZP3 gene is associated with Empty Follicle Syndrome and Female Infertility. PMID: 28886344
    4. Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. PMID: 24334245
    5. observed sequence variations in exons of ZP3 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    6. Eggs expressing glycoprotein huZP3, derived from transgenic mice, bind murine but not human sperm, implying that huZP3 acquires the same O-glycans as native mZP3. PMID: 14673092
    7. human and mouse ZP3 proteins are quite similar, and alternative explanations of taxon-specific sperm binding warrant exploration PMID: 15379548
    8. Binding sites for recombinant zona pellucida C (ZPC) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
    9. Peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 have a role similar to human ZP3. The mechanism of the response to the peptides involves influx of calcium, the G protein pathway, and a T-type calcium channel. PMID: 17192598
    10. may have a role in the development of primordial follicle before zona pellucida formation PMID: 18502569
    11. induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
    12. a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505
    13. The functional activity of human ZP3 resides in its C-terminal domain. PMID: 19246320

    顯示更多

    收起更多

  • 相關疾病:
    Oocyte maturation defect 3 (OOMD3)
  • 亞細胞定位:
    [Processed zona pellucida sperm-binding protein 3]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    ZP domain family, ZPC subfamily
  • 組織特異性:
    Expressed in oocytes (at protein level).
  • 數據庫鏈接:

    HGNC: 13189

    OMIM: 182889

    KEGG: hsa:7784

    STRING: 9606.ENSP00000378326

    UniGene: Hs.656137



主站蜘蛛池模板: 久青草久青草视频在线观看| 老熟妇仑乱视频一区二区| 五十老熟妇乱子伦免费观看| 欧美国产一区二区三区激情无套| 在厨房拨开内裤进入毛片| 亚洲欧洲日产国码在线| 国产精品女主播主要上线| 国产v在线最新观看视频| 波多野美乳人妻hd电影欧美| 亚洲综合色自拍一区| 久久亚洲精品成人av二次元| 国产精品午夜剧场免费观看| 精品国产亚洲一区二区三区| 粗大猛烈进出高潮视频免费看 | 18禁免费观看网站| 国产午夜精品一区二区三区极品| 久久―日本道色综合久久 | 人妻系列无码专区无码中出| 久久av一区二区三区| 亚洲精品一区二区三区婷婷月 | 亚洲人成黄网站69影院| 人妻无码一区二区三区| 99蜜桃在线观看免费视频网站| 一本色道久久综合亚州精品蜜桃| 亚洲综合色在线观看一区| 国产精品亚洲专区无码破解版| 久久99亚洲精品久久99果| 国产成人免费97在线| 人人妻人人澡人人爽偷拍台湾| 色偷偷偷在线视频播放| 国产动作大片中文字幕| 国产成人精品三级在线影院| 日韩人妻少妇一区二区| 欧洲成人一区二区三区| 亚洲a成人无码网站在线| 国产福利永久在线视频无毒不卡| 黑人巨大精品欧美一区二区| 妺妺窝人体色777777| 美女扒开腿让男人桶爽揉| av东京热无码专区| 欧美变态另类牲交zozo|