在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Zona pellucida sperm-binding protein 3 (ZP3), partial

  • 中文名稱:
    人ZP3重組蛋白
  • 貨號:
    CSB-EP027121HU1
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    ZP3
  • Uniprot No.:
  • 別名:
    HUMZP3; Processed zona pellucida sperm-binding protein 3; Sperm receptor; zona pellucida glycoprotein 3 (sperm receptor); Zona pellucida glycoprotein 3; zona pellucida glycoprotein 3A (sperm receptor); Zona pellucida glycoprotein ZP3; Zona pellucida protein C; Zona pellucida sperm binding protein 3 precursor; Zp-3; ZP3 372; ZP3 424; ZP3 474; ZP3; ZP3_HUMAN; ZP3A; ZP3A/ZP3B; ZP3B; ZPC
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    63.0kDa
  • 表達區域:
    23-346aa
  • 氨基酸序列
    QPLWLLQGGASHPETSVQPVLVECQEATLMVMVSKDLFGTGKLIRAADLTLGPEACEPLVSMDTEDVVRFEVGLHECGNSMQVTDDALVYSTFLLHDPRPVGNLSIVRTNRAEIPIECRYPRQGNVSSQAILPTWLPFRTTVFSEEKLTFSLRLMEENWNAEKRSPTFHLGDAAHLQAEIHTGSHVPLRLFVDHCVATPTPDQNASPYHTIVDFHGCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRNMIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQPHVMSQWSRS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.
  • 基因功能參考文獻:
    1. The zona pellucida-3 (ZP3) protein plays a pivotal role in oocyte and gamete development. PMID: 30341457
    2. The oocyte ZP3 expression was the main predictor of the fertilization capacity. PMID: 28204536
    3. Missense Mutation in ZP3 gene is associated with Empty Follicle Syndrome and Female Infertility. PMID: 28886344
    4. Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. PMID: 24334245
    5. observed sequence variations in exons of ZP3 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
    6. Eggs expressing glycoprotein huZP3, derived from transgenic mice, bind murine but not human sperm, implying that huZP3 acquires the same O-glycans as native mZP3. PMID: 14673092
    7. human and mouse ZP3 proteins are quite similar, and alternative explanations of taxon-specific sperm binding warrant exploration PMID: 15379548
    8. Binding sites for recombinant zona pellucida C (ZPC) glycoprotein are located both at the N- and C-terminus of proacrosin PMID: 15950651
    9. Peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 have a role similar to human ZP3. The mechanism of the response to the peptides involves influx of calcium, the G protein pathway, and a T-type calcium channel. PMID: 17192598
    10. may have a role in the development of primordial follicle before zona pellucida formation PMID: 18502569
    11. induces acrosome reactions which are protein kinase-C, protein tyrosine kinase, T-type Ca2+ channels, and extracellular Ca2+ dependent PMID: 18667750
    12. a significant decrease in acrosomal exocytosis mediated by both recombinant human ZP3 (p<0.005) and ZP4 (p<0.005) was observed in presence of the immune sera PMID: 19004505
    13. The functional activity of human ZP3 resides in its C-terminal domain. PMID: 19246320

    顯示更多

    收起更多

  • 相關疾病:
    Oocyte maturation defect 3 (OOMD3)
  • 亞細胞定位:
    [Processed zona pellucida sperm-binding protein 3]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    ZP domain family, ZPC subfamily
  • 組織特異性:
    Expressed in oocytes (at protein level).
  • 數據庫鏈接:

    HGNC: 13189

    OMIM: 182889

    KEGG: hsa:7784

    STRING: 9606.ENSP00000378326

    UniGene: Hs.656137



主站蜘蛛池模板: 国产成人精品日本亚洲第一区| 久久天天躁狠狠躁夜夜2o2o| 久久中文骚妇内射| 国模无码视频一区二区三区| 欧美性猛交xxxx乱大交丰满| 成年无码av片在线免缓冲| 久久人人97超碰caoporen| 国产奶头好大揉着好爽视频 | 农村乱人伦一区二区| 18禁黄网站禁片免费观看女女| 18禁超污无遮挡无码免费动态图| 人妻色综合网站| 色先锋资源久久综合5566| 性一交一乱一伦一| 国产午夜福利久久精品| 国产乱人伦在线播放| 亚洲精品欧美精品日韩精品| 蜜桃av蜜臀av色欲av麻| 亚洲熟妇无码av| 国产精品高潮呻吟av久久4虎| 亚洲婷婷综合色香五月| 国产自在自线午夜精品| 噜噜噜亚洲色成人网站∨| 日韩av高清无码| 日韩精品一区二区大桥未久| 国产免费极品av吧在线观看| 亚洲精品自在在线观看| 日本不卡不码高清视频| 亚洲精品综合欧美一区二区三区| 性色av无码不卡中文字幕| 热久久美女精品天天吊色| 国产又粗又猛又爽的视频a片| 九九视频免费精品视频| 国产最新进精品视频| 久久精品无码一区二区app| 中文字幕久久久久人妻| 国产精品美女久久久| 色喜国模李晴超大尺度| 肥白大屁股bbwbbwhd| 97精品国产手机| 中文字幕亚洲无线码一区女同|