在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Zinc finger protein 57 homolog (ZFP57)

  • 中文名稱:
    人ZFP57重組蛋白
  • 貨號:
    CSB-YP865138HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ZFP57重組蛋白
  • 貨號:
    CSB-EP865138HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人ZFP57重組蛋白
  • 貨號:
    CSB-EP865138HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ZFP57重組蛋白
  • 貨號:
    CSB-BP865138HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ZFP57重組蛋白
  • 貨號:
    CSB-MP865138HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ZFP57
  • Uniprot No.:
  • 別名:
    ZFP57; C6orf40; ZNF698; Zinc finger protein 57 homolog; Zfp-57; Zinc finger protein 698
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-452
  • 氨基酸序列
    MAAGEPRSLL FFQKPVTFED VAVNFTQEEW DCLDASQRVL YQDVMSETFK NLTSVARIFL HKPELITKLE QEEEQWRETR VLQASQAGPP FFCYTCGKCF SRRSYLYSHQ FVHNPKLTNS CSQCGKLFRS PKSLSYHRRM HLGERPFCCT LCDKTYCDAS GLSRHRRVHL GYRPHSCSVC GKSFRDQSEL KRHQKIHQNQ EPVDGNQECT LRIPGTQAEF QTPIARSQRS IQGLLDVNHA PVARSQEPIF RTEGPMAQNQ ASVLKNQAPV TRTQAPITGT LCQDARSNSH PVKPSRLNVF CCPHCSLTFS KKSYLSRHQK AHLTEPPNYC FHCSKSFSSF SRLVRHQQTH WKQKSYLCPI CDLSFGEKEG LMDHWRGYKG KDLCQSSHHK CRVILGQWLG FSHDVPTMAG EEWKHGGDQS PPRIHTPRRR GLREKACKGD KTKEAVSILK HK
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.
  • 基因功能參考文獻:
    1. transient neonatal diabetes type 1 is associated with ZFP57 mutations PMID: 27075368
    2. ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth PMID: 24469060
    3. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. PMID: 24618825
    4. These data identify ZFP57 as a candidate gene underlying reported MHC disease associations, notably for putative regulatory variants associated with cancer and HIV-1. PMID: 24193346
    5. Mouse and human ZFP57 are orthologs despite relatively low sequence identity. PMID: 24135613
    6. ZFP57 vZFP57 vZFP57 PMID: 23748067
    7. hZFP57 mutations and hypomethylation of the TNDM1 imprinted control region both associated with Transient Neonatal Diabetes Mellitus type 1 result in loss of hZFP57 binding to the TNDM1 locus. PMID: 23499433
    8. no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases PMID: 21863059
    9. this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS PMID: 19632365
    10. Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features. PMID: 18622393
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851445

    顯示更多

    收起更多

  • 相關疾病:
    Transient neonatal diabetes mellitus 1 (TNDM1)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily
  • 數據庫鏈接:

    HGNC: 18791

    OMIM: 601410

    KEGG: hsa:346171

    UniGene: Hs.156326



主站蜘蛛池模板: 99这里有精品视频视频| 无码高潮又爽又黄a片软件| 亚洲 欧美 天堂 综合| 欧美 国产 日产 韩国 在线 | 久久人人97超碰国产公开| 国内a∨免费播放| 我和亲妺妺乱的性视频| 国产欧美va欧美va香蕉在线观看| 国产亚洲人成网站观看| 少妇无码av无码专区| 色一情一乱一伦一区二区三区日本| 亚洲最大成人综合网720p| 另类亚洲小说图片综合区| 熟妇的奶头又大又长奶水视频| 少妇裸体性生交| 国产午夜片无码区在线播放| 男ji大巴进入女人的视频小说| 麻豆成人久久精品二区三区免费| 久久不见久久见免费影院国语| 国产成人精品亚洲日本在线| 国产精品久久久国产盗摄| 日本黄漫动漫在线观看视频| 免费女人高潮流视频在线观看 | 亚洲欧美日韩国产成人精品影院| 中文国产乱码在线人妻一区二区| 日本欧美久久久久免费播放网 | 在线|国产精品女主播阳台| 国产草草影院ccyycom| 性色av一区二区三区无码| 中文字幕在线观看亚洲日韩| 国产好大好硬好爽免费不卡| 亚洲aⅴ在线无码播放毛片一线天| 丰满少妇被猛烈进入试看| 中出人妻中文字幕无码| 五月丁香综合缴情六月小说| 亚洲精品无码成人av电影网| 精品人妻系列无码人妻漫画| 大陆精大陆国产国语精品| 国产亚洲综合欧美视频| 日本又黄又爽gif动态图| 久久人人爽人人爽人人片av东京热|