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  4. ZFP57 Antibody, FITC conjugated

ZFP57 Antibody, FITC conjugated

  • 中文名稱：
    ZFP57兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA865138LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZFP57 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZFP57
  • 別名：
    ZFP57 antibody; C6orf40 antibody; ZNF698 antibody; Zinc finger protein 57 homolog antibody; Zfp-57 antibody; Zinc finger protein 698 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Zinc finger protein 57 homolog protein (183-295AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.
  • 基因功能參考文獻：
    1. transient neonatal diabetes type 1 is associated with ZFP57 mutations PMID: 27075368
    2. ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth PMID: 24469060
    3. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. PMID: 24618825
    4. These data identify ZFP57 as a candidate gene underlying reported MHC disease associations, notably for putative regulatory variants associated with cancer and HIV-1. PMID: 24193346
    5. Mouse and human ZFP57 are orthologs despite relatively low sequence identity. PMID: 24135613
    6. ZFP57 vZFP57 vZFP57 PMID: 23748067
    7. hZFP57 mutations and hypomethylation of the TNDM1 imprinted control region both associated with Transient Neonatal Diabetes Mellitus type 1 result in loss of hZFP57 binding to the TNDM1 locus. PMID: 23499433
    8. no evidence for ZFP57 alterations as a major cause in sporadic Beckwith-Wiedemann Syndrome cases PMID: 21863059
    9. this study does not provide evidence that ZFP57 mutations are the cause of 11p15-hypomethylation in Silver-Russell syndrome (SRS) patients and contribute to the aetiology of SRS PMID: 19632365
    10. Study reports mutations in ZFP57, which encodes a zinc-finger transcription factor expressed in early development, in seven pedigrees with a shared pattern of mosaic hypomethylation and a conserved range of clinical features. PMID: 18622393
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851445

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  • 相關疾病：
    Transient neonatal diabetes mellitus 1 (TNDM1)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily
  • 數據庫鏈接：

    HGNC: 18791

    OMIM: 601410

    KEGG: hsa:346171

    UniGene: Hs.156326



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