在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ubiquitin-conjugating enzyme E2 E1 (UBE2E1)

  • 中文名稱:
    人UBE2E1重組蛋白
  • 貨號:
    CSB-YP025448HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人UBE2E1重組蛋白
  • 貨號:
    CSB-EP025448HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人UBE2E1重組蛋白
  • 貨號:
    CSB-EP025448HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人UBE2E1重組蛋白
  • 貨號:
    CSB-BP025448HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人UBE2E1重組蛋白
  • 貨號:
    CSB-MP025448HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    UB2E1_HUMAN; UbcH6; Ube2e1; Ubiquitin carrier protein E1; Ubiquitin conjugating enzyme E2E 1 (homologous to yeast UBC4/5); Ubiquitin conjugating enzyme E2E 1; Ubiquitin-conjugating enzyme E2 E1; ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase E1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-193
  • 氨基酸序列
    SDDDSRAST SSSSSSSSNQ QTEKETNTPK KKESKVSMSK NSKLLSTSAK RIQKELADIT LDPPPNCSAG PKGDNIYEWR STILGPPGSV YEGGVFFLDI TFTPEYPFKP PKVTFRTRIY HCNINSQGVI CLDILKDNWS PALTISKVLL SICSLLTDCN PADPLVGSIA TQYMTNRAEH DRMARQWTKR YAT
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.
  • 基因功能參考文獻:
    1. UBE2E1 expression was adversely correlated with AML survival; UBE2E1 expression was negatively correlated with patients' response to induction chemotherapy PMID: 27855695
    2. IPO11 provides protection in another way, the researchers found. The transport receptor also shuttles UBE2E1, an enzyme necessary for PTEN ubiquitination, into the nucleus. Thanks to IPO11, normal cells keep all of their UBE2E1 in the nucleus, allowing PTEN to continue functioning in the cytoplasm. In cells lacking IPO11, UBE2E1 remains in the cytoplasm and promotes the destruction of PTEN. PMID: 28258103
    3. study reveals that UbE2E1 is an in vivo E2 for the PRC1 ligase complex and thus plays an important role in the regulation of H2A Lys-119 monoubiquitination PMID: 28073915
    4. Auto-ubiquitination of Ube2E1 is intramolecular.RNF4 enhances Ube2E1 self-ubiquitination. PMID: 25960396
    5. USP7 is critical in maintaining the steady state levels of UbE2E1 in cells. PMID: 23603909
    6. isolated ISG15-modified and unmodified UbcH6 proteins, and analyzed their abilities to form thioester intermediates with ubiquitin PMID: 16428300
    7. UbcH6 and ataxin-1 are E2-substrate cognate pairs in the ubiquitin-proteasome system. PMID: 18439907
    8. UbcH6 modulates the transcriptional repression activity of ataxin-1 by modulating the degradation of ataxin-1. PMID: 18519031
    9. E1 ligase of the proteasome is inhibitd by ziram and has a role in preventing dopaminergic cell damage PMID: 18818210
    10. Smallangle X-ray scattering experiments show that the Lys63 tetra-Ub chain is dynamic in solution, adopting an ensemble of conformations that are more compact than the extended form in the crystal. PMID: 19664638

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Ubiquitin-conjugating enzyme family
  • 數據庫鏈接:

    HGNC: 12477

    OMIM: 602916

    KEGG: hsa:7324

    STRING: 9606.ENSP00000303709

    UniGene: Hs.164853



主站蜘蛛池模板: 国产精品aⅴ在线观看| 少妇无套内谢久久久久| 亚洲精品综合一区二区三区在线| 鲁一鲁一鲁一鲁一曰综合网| 伊人久久精品无码二区麻豆| 亚洲愉拍99热成人精品| 国产成人无码一区二区三区在线 | 人妻三级日本香港三级极97| 亚洲精品99久久久久中文字幕| 黑人粗长大战亚洲女| 日本午夜精品一区二区三区电影 | 欧美午夜成人片在线观看| 丰满少妇熟乱xxxxx视频| 久久精品中文字幕一区二区三区 | 亚洲乱码一区av春药高潮| 欧美偷窥清纯综合图区| 男女真人国产牲交a做片野外| 日韩精品亚洲人旧成在线| 野外亲子乱子伦视频丶| 在线播放亚洲第一字幕| 国产自愉自愉免费精品七区| 日韩国产网曝欧美第一页| 国产新婚夫妇叫床声不断| 天天躁日日躁狠狠躁av| 欧美成人一区二免费视频| 亚洲精品无码成人片| 国产日韩综合一区在线观看| 99亚洲男女激情在线观看| 免费视频爱爱太爽了 | 人妻中文乱码在线网站| 精品国产人成亚洲区| 人妻免费一区二区三区最新| 亚洲国产av无码综合原创国产 | 中文字幕一区二区三区精华液| 亚洲国产成人精品无码区宅男| 把女邻居弄到潮喷的性经历| 午夜片无码区私人影院| 伊人大香人妻在线播放| 任我爽橹在线精品视频| 久久久久久久99精品免费观看| 中文字幕无码不卡免费视频|