在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tripartite motif-containing protein 72 (TRIM72), partial

In Stock
  • 中文名稱:
    人TRIM72重組蛋白
  • 貨號:
    CSB-BP744394HU
  • 規(guī)格:
    ¥3168
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Mitsugumin-53 Short name: Mg53
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    partial
  • 來源:
    Baculovirus
  • 分子量:
    33.4 kDa
  • 表達區(qū)域:
    1-269aa
  • 氨基酸序列
    MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRVFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMKYCLVTSRLQKILAESPPPARLDIQLPIIS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
  • 基因功能參考文獻:
    1. serum TRIM72 may be a potential biomarker for the diagnosis and the prognosis of colon cancer. PMID: 29806630
    2. MG53 is an effective biomarker of myocardial injury and dysfunction in murine hearts. However, MG53 is not expressed in human heart and therefore does not hold utility as a clinical biomarker of myocardial injury PMID: 26790476
    3. MG53 is a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing PMID: 26306047
    4. Zn(2+) interacts with MG53 in protection against injury to the cell membrane PMID: 25869134
    5. MG53 induces FAK ubiquitination with the aid of UBE2H during skeletal myogenesis. PMID: 24344130
    6. MG53/TRIM72 protein can be directly applied as a therapeutic agent to increase membrane repair capacity of many cell types. PMID: 23699904
    7. data reveal NM-IIA as a key cytoskeleton motor protein that facilitates vesicle trafficking during MG53-mediated cell membrane repair PMID: 22253476
    8. membrane-delimited interaction between MG53 and PTRF contributes to initiation of cell membrane repair PMID: 21343302
    9. MG53, annexin A1, and dysferlin localize to the t-tubule network and show enriched labeling at longitudinal tubules of the t-system in overstretch PMID: 21412170
    10. Crystal structure of PRY-SPRY domain of human TRIM72. PMID: 19967786
    11. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 19129174

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane, sarcolemma. Cytoplasmic vesicle membrane.
  • 蛋白家族:
    TRIM/RBCC family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 32671

    OMIM: 613288

    KEGG: hsa:493829

    STRING: 9606.ENSP00000312675

    UniGene: Hs.661859



主站蜘蛛池模板: yyyy11111少妇影院| 久久精品人妻少妇一区二区三区 | 亚洲图欧洲图自拍另类高清| 欧美 日韩 亚洲 精品二区| 人人妻人人澡人人爽秒播| 四虎永久在线精品无码视频| 国产在热线精品视频99公交| 女人19水真多免费毛片| 国产婷婷色一区二区三区| 天堂а√在线中文在线新版 | 国产一区二区三区自产| 人妻精品人妻无码一区二区三区 | h漫全彩纯肉无码网站| 国产精品v片在线观看不卡| 女人被狂躁c到高潮视频| av在线亚洲欧洲日产一区二区| 国产成人久久久精品二区三区| 中文字字幕人妻中文| 欧美性猛交xxxx乱大交极品| 中国肥老太婆高清video| 国产精品线路一线路二| 一本大道无码人妻精品专区| 护士的小嫩嫩好紧好爽| 久热这里只有精品99| 亚洲最大av网站在线观看| 国产精品原创巨作av| 呻吟国产av久久一区二区| 亚洲人成电影综合网站色www| 免费人成视频在线播放| 国产精品亚洲专区无码web| 亚洲—本道 在线无码av发| 国产99久久久欧美黑人刘玥| 一区二区三区无码被窝影院| 国产xxxx69真实实拍| 黄床片30分钟免费视频教程| 色翁荡熄又大又硬又粗又动态图| 极品嫩模高潮叫床| 亚洲乱亚洲乱妇无码麻豆| 无码国产成人午夜电影在线观看| 国产99在线 | 亚洲| aaa欧美色吧激情视频|