在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Human Tripartite motif-containing protein 72(TRIM72) ELISA kit

Human Tripartite motif-containing protein 72(TRIM72) ELISA kit

  • 中文名稱：
    人三結(jié)構(gòu)域包含蛋白72(TRIM72)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL024511HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人三結(jié)構(gòu)域包含蛋白72(TRIM72)酶聯(lián)免疫試劑盒（CSB-EL024511HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的TRIM72含量。TRIM72是一種三結(jié)構(gòu)域蛋白，參與細胞膜修復(fù)和抗氧化功能，可能通過膜修復(fù)、抗氧化和線粒體功能修復(fù)等機制減緩神經(jīng)退行性疾病如肌萎縮側(cè)索硬化癥（ALS）的神經(jīng)元損害。試劑盒檢測范圍為25 pg/mL-1600 pg/mL，適用于探究TRIM72在肌肉損傷修復(fù)、再生醫(yī)學(xué)或疾病模型（如心肌缺血、骨骼肌病變等）中的分子機制研究；可滿足細胞生物學(xué)、分子病理學(xué)等領(lǐng)域的基礎(chǔ)科研需求本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    LOC493829 ELISA Kit; Mg53 ELISA Kit; Mitsugumin-53 ELISA Kit; TRI72_HUMAN ELISA Kit; trim72 ELISA Kit; Tripartite motif containing 72 ELISA Kit; Tripartite motif containing protein 72 ELISA Kit; Tripartite motif-containing protein 72 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    25 pg/mL-1600 pg/mL
  • 靈敏度：
    6.25 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TRIM72 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %94
    Range %89-98
    1:2Average %92
    Range %86-95
    1:4Average %85
    Range %80-89
    1:8Average %92
    Range %86-97
  • 回收率：
    The recovery of human TRIM72 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10398-107
    EDTA plasma (n=4)9590-99
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    16002.508 2.310 2.409 2.284
    8001.442 1.345 1.394 1.269
    4000.779 0.816 0.798 0.673
    2000.463 0.446 0.455 0.330
    1000.322 0.317 0.320 0.195
    500.239 0.231 0.235 0.110
    250.198 0.192 0.195 0.070
    00.126 0.124 0.125
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

靶點詳情

  • 功能：
    Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
  • 基因功能參考文獻：
    1. serum TRIM72 may be a potential biomarker for the diagnosis and the prognosis of colon cancer. PMID: 29806630
    2. MG53 is an effective biomarker of myocardial injury and dysfunction in murine hearts. However, MG53 is not expressed in human heart and therefore does not hold utility as a clinical biomarker of myocardial injury PMID: 26790476
    3. MG53 is a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing PMID: 26306047
    4. Zn(2+) interacts with MG53 in protection against injury to the cell membrane PMID: 25869134
    5. MG53 induces FAK ubiquitination with the aid of UBE2H during skeletal myogenesis. PMID: 24344130
    6. MG53/TRIM72 protein can be directly applied as a therapeutic agent to increase membrane repair capacity of many cell types. PMID: 23699904
    7. data reveal NM-IIA as a key cytoskeleton motor protein that facilitates vesicle trafficking during MG53-mediated cell membrane repair PMID: 22253476
    8. membrane-delimited interaction between MG53 and PTRF contributes to initiation of cell membrane repair PMID: 21343302
    9. MG53, annexin A1, and dysferlin localize to the t-tubule network and show enriched labeling at longitudinal tubules of the t-system in overstretch PMID: 21412170
    10. Crystal structure of PRY-SPRY domain of human TRIM72. PMID: 19967786
    11. Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 19129174

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane, sarcolemma. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    TRIM/RBCC family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32671

    OMIM: 613288

    KEGG: hsa:493829

    STRING: 9606.ENSP00000312675

    UniGene: Hs.661859



主站蜘蛛池模板： 欧美黑人与白人精品a片| 日韩欧美人妻一区二区三区| 伊人久久大香线蕉亚洲| 国产成人8x人在线视频软件| 亚洲精品综合欧美一区二区| 99久久久无码国产精品9| 老司机亚洲精品影院无码| 国产白丝无码免费视频| 波多野结衣一区二区免费视频| 玩超薄丝袜人妻的经历| 亚洲人成电影在线播放| 欧美级特黄aaaaaa片| 99久久精品6在线播放| 国产成人精品一区二区在线小狼| 精品三级av无码一区| 大香伊蕉在人线国产最新75| 久久精品伊人久久精品伊人| 中国丰满熟妇xxxx性| 亚洲vs日韩vs欧美vs久久| 男女扒开双腿猛进入免费看污| 欧美老熟妇乱子| 国内精品伊人久久久久777| 色欲天天网站欧美成人福利网| 久久精品青青草原伊人| 免费吃奶摸下激烈视频| 精品偷自拍另类在线观看| 97se狠狠狠狠狼鲁亚洲综合色 | 中文字幕日本特黄aa毛片| 国产男女猛烈视频在线观看| 极品少妇小泬50pthepon| 国模无码一区二区三区| 国产精品人成在线播放新网站| 中国猛少妇色xxxxx| 无码国产色欲xxxx视频| 狼色精品人妻在线视频免费| 国产高清av喷水白丝护士| 夜夜躁很很躁日日躁麻豆| 色与欲影视天天看综合网| 国产精品自在线一区| 国产伦精品一区二区三区妓女| 亚洲熟妇无码八av在线播放|