在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human TRAF2 and NCK-interacting protein kinase (TNIK), partial

Recombinant Human TRAF2 and NCK-interacting protein kinase (TNIK), partial

  • 中文名稱：
    人TNIK重組蛋白
  • 貨號：
    CSB-YP890916HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TNIK重組蛋白
  • 貨號：
    CSB-EP890916HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TNIK重組蛋白
  • 貨號：
    CSB-EP890916HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TNIK重組蛋白
  • 貨號：
    CSB-BP890916HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TNIK重組蛋白
  • 貨號：
    CSB-MP890916HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    EC 2.7.11.1 ; KIAA0551 ; Tnik; TNIK_HUMAN; Traf2 and NCK interacting kinase; Traf2 and NCK-interacting protein kinase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
  • 基因功能參考文獻：
    1. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. PMID: 27562646
    2. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells. PMID: 28467797
    3. results provide new evidence that TNIK may be involved in the proliferation of multiple myeloma IM-9 cells and in the anti-cancer activity of dovitinib via inhibition of the endogenous Wnt signaling pathway. PMID: 26995282
    4. Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik (-/-) phenotype in the murine model PMID: 27106596
    5. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    6. Our results demonstrated that TNIK might play a crucial role in pancreatic carcinogenesis and serve as a novel therapeutic target of pancreatic cancer. PMID: 26269113
    7. High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients. PMID: 26499327
    8. Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK. PMID: 26645429
    9. nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma PMID: 25160513
    10. Dynamic change of TNIK offers a way to protect cells from outside stimulus. PMID: 23355318
    11. TNIK mediates proliferation and survival of EBV-transformed B-cells. PMID: 22904686
    12. TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor. PMID: 21710359
    13. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, autosomal recessive 54 (MRT54)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 數據庫鏈接：

    HGNC: 30765

    OMIM: 610005

    KEGG: hsa:23043

    STRING: 9606.ENSP00000399511

    UniGene: Hs.34024



主站蜘蛛池模板： 色综合欧美亚洲国产| 亚洲乱码国产乱码精品精| 国产精品久久久久久亚洲影视内衣 | 亚洲无人区码一码二码三码的含义| 综合激情久久综合激情| 久久久久久亚洲精品a片成人| 色综合久久久无码中文字幕波多| 婷婷综合另类小说色区 | 亚洲图片小说激情综合| 天天躁夜夜躁av天天爽| 亚洲毛片不卡av在线播放一区| 亚洲中文字幕av无码区| 无码人妻斩一区二区三区| 性色欲网站人妻丰满中文久久不卡 | 国产av毛片亚洲含羞草社| 狠狠做五月深爱婷婷伊人| 精品欧洲av无码一区二区| 特黄特级毛片免费视频| 综合图片亚洲综合网站| 上司人妻互换hd无码| 久久精品手机观看| 久久国产成人午夜av影院| 亚洲va中文字幕无码久久| 人妻精品久久无码区| 免费人成在线观看网站| 久久久久亚洲精品男人的天堂| 永久免费男同av无码入口| 亚洲精品成人网站在线| 国产口爆吞精在线视频2020版| 99re6热视频这里只精品首页 | 久久综合精品无码av一区二区三区| 熟女乱牛牛视频在线观看| 中文字幕美人妻亅u乚一596| 波多野结衣aⅴ在线| 美女mm131午夜福利在线| 国产高清不卡一区二区 | 国产亚洲精品久久久久久打不开| 天码欧美日本一道免费| 漂亮人妻被中出中文字幕 | 婷婷色怡春院| 好吊色欧美一区二区三区视频|