在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TNIK Antibody, FITC conjugated

TNIK Antibody, FITC conjugated

  • 中文名稱：
    TNIK兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA023998LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TNIK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody; Traf2 and NCK-interacting protein kinase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
  • 基因功能參考文獻：
    1. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. PMID: 27562646
    2. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells. PMID: 28467797
    3. results provide new evidence that TNIK may be involved in the proliferation of multiple myeloma IM-9 cells and in the anti-cancer activity of dovitinib via inhibition of the endogenous Wnt signaling pathway. PMID: 26995282
    4. Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik (-/-) phenotype in the murine model PMID: 27106596
    5. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    6. Our results demonstrated that TNIK might play a crucial role in pancreatic carcinogenesis and serve as a novel therapeutic target of pancreatic cancer. PMID: 26269113
    7. High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients. PMID: 26499327
    8. Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK. PMID: 26645429
    9. nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma PMID: 25160513
    10. Dynamic change of TNIK offers a way to protect cells from outside stimulus. PMID: 23355318
    11. TNIK mediates proliferation and survival of EBV-transformed B-cells. PMID: 22904686
    12. TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor. PMID: 21710359
    13. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, autosomal recessive 54 (MRT54)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 數據庫鏈接：

    HGNC: 30765

    OMIM: 610005

    KEGG: hsa:23043

    STRING: 9606.ENSP00000399511

    UniGene: Hs.34024



主站蜘蛛池模板： 色无码av在线播放| 欧美亚洲另类 丝袜综合网| 好爽太紧了舒服视频| 国产尤物精品自在拍视频首页 | 久久超乳爆乳中文字幕| 99久久综合狠狠综合久久| 免费国产乱理伦片在线观看| 成人免费无码大片a毛片户外 | 天堂网www在线资源中文| 欧美成人看片一区二三区图文| 亚洲s久久久久一区二区| 欧美性猛交aaaa片黑人| 国产精品久久精品国产| 国产精品高清一区二区不卡片| 久久国产亚洲精选av| 亚洲成a人v欧美综合天堂麻豆| 无码一区二区波多野结衣播放搜索| 亚洲国产午夜精品理论片妓女| 特级a欧美做爰片第一次| 国产精品久久无码一区| 欧美人与动欧交视频| 亚洲精品久久7777777国产| 好爽好舒服要高潮了视频| 黑人玩弄出轨人妻松雪| 醉酒后少妇被疯狂内射视频| 精品无人乱码高清| 最近的中文字幕在线看视频| 狠狠躁夜夜躁人人躁婷婷视频| 国产精品久久久久影院嫩草| 中文字幕婷婷日韩欧美亚洲| 国产精品高潮呻吟av久久黄| 亚洲日韩久久综合中文字幕 | 国产亚洲视频在线观看网址| 少妇仑乱a毛片| 国产精品a成v人在线播放| 四虎成人欧美精品在永久在线| 国产末成年女av片一区二区 | 国产精品乱码人妻一区二区三区| 爆乳护士一区二区三区在线播放| 国偷自产视频一区二区久| 一二三四免费观看在线视频中文版|