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  4. TNIK Antibody, Biotin conjugated

TNIK Antibody, Biotin conjugated

  • 中文名稱：
    TNIK兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA023998LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) TNIK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody; Traf2 and NCK-interacting protein kinase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
  • 基因功能參考文獻(xiàn)：
    1. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. PMID: 27562646
    2. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells. PMID: 28467797
    3. results provide new evidence that TNIK may be involved in the proliferation of multiple myeloma IM-9 cells and in the anti-cancer activity of dovitinib via inhibition of the endogenous Wnt signaling pathway. PMID: 26995282
    4. Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik (-/-) phenotype in the murine model PMID: 27106596
    5. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    6. Our results demonstrated that TNIK might play a crucial role in pancreatic carcinogenesis and serve as a novel therapeutic target of pancreatic cancer. PMID: 26269113
    7. High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients. PMID: 26499327
    8. Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK. PMID: 26645429
    9. nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma PMID: 25160513
    10. Dynamic change of TNIK offers a way to protect cells from outside stimulus. PMID: 23355318
    11. TNIK mediates proliferation and survival of EBV-transformed B-cells. PMID: 22904686
    12. TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor. PMID: 21710359
    13. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639

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  • 相關(guān)疾病：
    Mental retardation, autosomal recessive 54 (MRT54)
  • 亞細(xì)胞定位：
    Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30765

    OMIM: 610005

    KEGG: hsa:23043

    STRING: 9606.ENSP00000399511

    UniGene: Hs.34024



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