在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TNIK Antibody

TNIK Antibody

  • 中文名稱：
    TNIK兔多克隆抗體
  • 貨號：
    CSB-PA023998LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA023998LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023998LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA023998LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TNIK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody; Traf2 and NCK-interacting protein kinase antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TNIK Antibody (CSB-PA023998LA01HU)，的標記方式是Non-conjugated。對于TNIK Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA023998LB01HU TNIK Antibody, HRP conjugated ELISA
    FITC CSB-PA023998LC01HU TNIK Antibody, FITC conjugated
    Biotin CSB-PA023998LD01HU TNIK Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
  • 基因功能參考文獻：
    1. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. PMID: 27562646
    2. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells. PMID: 28467797
    3. results provide new evidence that TNIK may be involved in the proliferation of multiple myeloma IM-9 cells and in the anti-cancer activity of dovitinib via inhibition of the endogenous Wnt signaling pathway. PMID: 26995282
    4. Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik (-/-) phenotype in the murine model PMID: 27106596
    5. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    6. Our results demonstrated that TNIK might play a crucial role in pancreatic carcinogenesis and serve as a novel therapeutic target of pancreatic cancer. PMID: 26269113
    7. High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients. PMID: 26499327
    8. Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK. PMID: 26645429
    9. nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma PMID: 25160513
    10. Dynamic change of TNIK offers a way to protect cells from outside stimulus. PMID: 23355318
    11. TNIK mediates proliferation and survival of EBV-transformed B-cells. PMID: 22904686
    12. TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor. PMID: 21710359
    13. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639

    顯示更多

    收起更多

  • 相關疾病：
    Mental retardation, autosomal recessive 54 (MRT54)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 數據庫鏈接：

    HGNC: 30765

    OMIM: 610005

    KEGG: hsa:23043

    STRING: 9606.ENSP00000399511

    UniGene: Hs.34024



主站蜘蛛池模板： 樱花影院电视剧免费| 成人无码亚洲精品无码 | 国产精品无码v在线观看| 艳妇臀荡乳欲伦交换h在线观看| 国产精品久久777777| 久久这里只精品国产免费9| 国产美女视频免费观看网址| 久久久久久久精品成人热色戒汤唯 | 久久99精品国产自在现线小黄鸭| 亚洲欧美成αⅴ人在线观看| 欧美成年网站色a| 日日碰狠狠丁香久燥| 亚洲国产精品成人天堂| 欧美 国产 亚洲视频| 熟女chachacha性少妇| 男人把女人桶到爽免费应用| 日韩欧美在线综合网另类| 亚洲aⅴ天堂av天堂无码麻豆 | 毛多水多www偷窥小便| 三级在线看中文字幕完整版| 西西人体大胆扒开下部337卩 | 欧美日韩不卡合集视频| 日韩精品久久无码中文字幕| 亚洲一区激情校园小说| 欧美熟妇性xxxx交潮喷| 精品少妇爆乳无码av无码专区| 中文字幕亚洲日韩无线码| 欧洲av成本人在线观看免费| 欧美另类bbbxxxxx另类| 男女性色大片免费网站| 国产精品福利自产拍在线观看| 国内揄拍国内精品人妻浪潮av | 亚洲熟妇国产熟妇肥婆| 国产97超碰人人做人人爱| 无码精品日韩专区| 亚洲精品国产av成拍色拍婷婷 | 无码毛片一区二区本码视频| 80s国产成年女人毛片| 丰满岳乱妇在线观看中字 | 又爽又黄又无遮挡网站| 无遮挡十八禁污污污网站|