在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Synembryn-A (RIC8A)

  • 中文名稱:
    人RIC8A重組蛋白
  • 貨號:
    CSB-YP878847HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RIC8A重組蛋白
  • 貨號:
    CSB-EP878847HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RIC8A重組蛋白
  • 貨號:
    CSB-EP878847HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RIC8A重組蛋白
  • 貨號:
    CSB-BP878847HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RIC8A重組蛋白
  • 貨號:
    CSB-MP878847HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RIC8A
  • Uniprot No.:
  • 別名:
    MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); RIC8; RIC8A; RIC8A_HUMAN; Synembryn-A
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-531
  • 氨基酸序列
    MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL VSVLEQGLPP SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV SEGSVPESAD MDVVLESLKC LCNLVLSSPV AQMLAAEARL VVKLTERVGL YRERSFPHDV QFFDLRLLFL LTALRTDVRQ QLFQELKGVR LLTDTLELTL GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV DEEDAALYRH LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK FLKAQVLPPL RDVRTRPEVG EMLRNKLVRL MTHLDTDVKR VAAEFLFVLC SESVPRFIKY TGYGNAAGLL AARGLMAGGR PEGQYSEDED TDTDEYKEAK ASINPVTGRV EEKPPNPMEG MTEEQKEHEA MKLVTMFDKL SRNRVIQPMG MSPRGHLTSL QDAMCETMEQ QLSSDPDSDP D
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
  • 基因功能參考文獻:
    1. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2. PMID: 25074811
    2. Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o)-GDP complex in a cellular environment. PMID: 25480567
    3. Ric-8A co-localized with Vps34 at the midbody. PMID: 24466196
    4. The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A. PMID: 23665327
    5. NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response PMID: 22384181
    6. RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A PMID: 21880739
    7. Ric-8A is critical for growth factor receptor-induced actin cytoskeletal reorganization PMID: 21771786
    8. Ric-8A signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle. PMID: 20479129

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 蛋白家族:
    Synembryn family
  • 數據庫鏈接:

    HGNC: 29550

    OMIM: 609146

    KEGG: hsa:60626

    STRING: 9606.ENSP00000325941

    UniGene: Hs.592292



主站蜘蛛池模板: 国产精品午夜福利不卡| 黑鬼大战白妞高潮喷白浆| 97久久精品无码一区二区| 特黄做受又硬又粗又大视频小说| 欧美老肥熟妇多毛xxxxx| 国产内射爽爽大片| 色翁荡熄又大又硬又粗又视频| 中文精品久久久久人妻| 欧美日韩人成视频在线播放 | 双乳奶水饱满少妇呻吟| 国产成人精品一区二区三区视频| 欧美一区二区三区视频在线观看| 精品服丝袜无码视频一区 | 亚洲中文字幕久久无码| 国产精品久久无码不卡| 日本亚州视频在线八a| 国产免费又色又爽粗视频| 国产成人精品男人的天堂| 国产av一区二区精品凹凸| 国产 中文 制服丝袜 另类| 久久国产福利国产秒拍飘飘网 | 青青青青国产免费线在线观看| 国产精品久久久久久久伊一| 国产在线精品一区在线观看| 一 级 黄 色 片免费网站| 琪琪电影午夜理论片八戒八戒| 免费va人成视频网站全| 国产内射爽爽大片| 国产剧情国产精品一区| 国产区又黄又硬高潮的视频| 成人福利国产精品视频| 成人爽a毛片免费啪啪| 国产99视频精品免费视看9| 中文字幕免费无码专区| 亚洲国产精品久久久久久无码| 免费看无码毛视频成片| 亚洲精品无码久久毛片波多野吉衣 | 久久久久青草线综合超碰| 免费观看男女性高视频| 亚洲日韩久久综合中文字幕 | 欧洲美熟女乱又伦免费视频|