在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RIC8A Antibody

RIC8A Antibody

  • 中文名稱：
    RIC8A兔多克隆抗體
  • 貨號：
    CSB-PA878847ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA878847ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RIC8A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RIC8A
  • 別名：
    MGC104517 antibody; MGC131931 antibody; MGC148073 antibody; MGC148074 antibody; Protein Ric-8A antibody; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) antibody; RIC8 antibody; RIC8A antibody; RIC8A_HUMAN antibody; Synembryn-A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Synembryn-A protein (362-531AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
  • 基因功能參考文獻：
    1. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2. PMID: 25074811
    2. Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o)-GDP complex in a cellular environment. PMID: 25480567
    3. Ric-8A co-localized with Vps34 at the midbody. PMID: 24466196
    4. The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A. PMID: 23665327
    5. NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response PMID: 22384181
    6. RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A PMID: 21880739
    7. Ric-8A is critical for growth factor receptor-induced actin cytoskeletal reorganization PMID: 21771786
    8. Ric-8A signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle. PMID: 20479129

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    Synembryn family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29550

    OMIM: 609146

    KEGG: hsa:60626

    STRING: 9606.ENSP00000325941

    UniGene: Hs.592292



主站蜘蛛池模板： 动漫精品啪啪一区二区三区| 无码av中文一区二区三区| 亚洲国产精品一区二区制服| 国产乱人伦真实精品视频| 亚洲天堂男人影院| 国产xxxxx在线观看| 人人狠狠久久亚洲综合88| av中文字幕无码免费看| 玩弄人妻少妇500系列| 狠狠色噜噜狠狠狠狠色综合久| 69成人免费视频无码专区| 国产高清一区二区三区直播| 九九re6热在线视频精品66| 777久久精品一区二区三区无码| 无码少妇精品一区二区免费动态| 亚洲高潮喷水无码av电影| 国产偷国产偷亚州清高app| 乱女伦露脸对白在线播放| 日产国产精品亚洲系列| 亚洲精品久久久无码大桥未久| 大色综合色综合网站| 成人午夜视频精品一区| 蜜桃av久久久一区二区三区麻豆 | 亚洲春色av无码专区在线播放| 少妇高潮喷水惨叫久久久久电影| 国产大屁股喷水视频在线观看| 国产96在线 | 韩国| 国产乱人伦av在线麻豆a| 特级毛片内射www无码| 老子午夜精品无码| 久久国产热精品波多野结衣av| 天天影视性色香欲综合网| 国产老熟女伦老熟妇露脸| 亚洲午夜免费福利视频| 2020久久超碰国产精品最新| 天天狠天天透天干天天怕∴| 日本亚洲色大成网站www| 亚洲熟妇无码av不卡在线观看| 久久一日本综合色鬼综合色| 老太脱裤让老头玩ⅹxxxx| 国产成人欧美亚洲日韩电影|