在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Synaptotagmin-11 (SYT11), partial

  • 中文名稱(chēng):
    人SYT11重組蛋白
  • 貨號(hào):
    CSB-YP883595HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    人SYT11重組蛋白
  • 貨號(hào):
    CSB-EP883595HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    人SYT11重組蛋白
  • 貨號(hào):
    CSB-EP883595HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    人SYT11重組蛋白
  • 貨號(hào):
    CSB-BP883595HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    人SYT11重組蛋白
  • 貨號(hào):
    CSB-MP883595HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    SYT11
  • Uniprot No.:
  • 別名:
    DKFZp781D015; KIAA0080; MGC10881; MGC17226; Synaptotagmin 11; Synaptotagmin 12; Synaptotagmin XI; Synaptotagmin-11; Synaptotagmin11; Synaptotagmin12; SynaptotagminXI; SYT 11; SYT 12; Syt XI; Syt11; SYT11_HUMAN; SYT12; SytXI
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane. Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway.
  • 基因功能參考文獻(xiàn):
    1. ATP13A2 and SYT11 form a functional network in the regulation of the autophagy-lysosome pathway, which may contribute to forms of Parkinson's Disease-associated neurodegeneration. PMID: 27278822
    2. parkin deficiency induces synaptotagmin-11 accumulation and PD-like neurotoxicity in mouse models, which is reversed by SYT11 knockdown in the SNpc or knockout of SYT11 restricted to dopaminergic neuron PMID: 29311685
    3. In summary, This study supports the existence of association between Parkinson disease and markers in or around SYT11 PMID: 26944171
    4. The genetic variations of VAMP2, Synaptotagmin XI might be indication of the relationship between these genes and idiopathic generalized epilepsy PMID: 24164654
    5. parkin interacts with and ubiquitinates synaptotagmin XI PMID: 12925569
    6. Lack of disease-causing mutations in a detailed analysis of a large sample of familial and sporadic Parkinson's disease patients argues against a major role of mutations in the synaptotagmin XI gene in PD. PMID: 15354386
    7. Excessive expression of Syt11 can be associated with schizophrenia. PMID: 17192956

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasmic vesicle membrane; Single-pass membrane protein. Perikaryon. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Recycling endosome membrane; Single-pass membrane protein. Lysosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, phagosome. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Recycling endosome membrane; Single-pass membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Single-pass membrane protein. Perikaryon.
  • 蛋白家族:
    Synaptotagmin family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 19239

    OMIM: 608741

    KEGG: hsa:23208

    STRING: 9606.ENSP00000357307

    UniGene: Hs.32984



主站蜘蛛池模板: 韩国的无码av看免费大片在线| 香港三日本8a三级少妇三级99 | 国产在线高清视频无码| 少妇又色又紧又爽又刺激视频| 性做久久久久久久久| 国产69精品久久久久久久 | 国产激情电影综合在线看| 四虎影视在线观看2413| 亚洲成av人在线视| 亚洲高清无在码在线电影| 少妇人妻中文字幕污| 国产精品视频一区国模私拍| 少妇无码一区二区三区| 亚洲午夜私人影院在线观看| 久久久久99精品成人品| 国产性色播播毛片| 80s国产成年女人毛片| 日韩av在线观看免费| 免费无码作爱视频| 亚洲人成伊人成综合网久久久| 丰满人妻熟妇乱又伦精品软件| 国产精品99久久免费| 亚洲日韩国产中文其他| 久久成人a毛片免费观看网站 | 中文天堂网www新版资源在线| 久久精品a亚洲国产v高清不卡 | 欧美激烈精交gif动态图| 少妇被粗大猛进进出出| 国产麻豆剧传媒精品av | 一本精品99久久精品77 | 欧美人与性动交g欧美精器| 推油少妇久久99久久99久久| 狠狠精品久久久无码中文字幕| 欧美亚洲熟妇一区二区三区| 精品国产污污免费网站入口| k频道国产在线观看| 国产在线码观看超清无码视频| 欧美黑吊大战白妞| 久久久性色精品国产免费观看| 亚洲综合熟女久久久40p| 亚洲卡一卡二乱码新区仙踪|