在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Solute carrier family 26 member 9 (SLC26A9), partial

  • 中文名稱:
    人SLC26A9重組蛋白
  • 貨號:
    CSB-YP741974HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SLC26A9重組蛋白
  • 貨號:
    CSB-EP741974HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SLC26A9重組蛋白
  • 貨號:
    CSB-EP741974HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SLC26A9重組蛋白
  • 貨號:
    CSB-BP741974HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SLC26A9重組蛋白
  • 貨號:
    CSB-MP741974HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    SLC26A9
  • Uniprot No.:
  • 別名:
    SLC26A9; Solute carrier family 26 member 9; Anion transporter/exchanger protein 9
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane.
  • 基因功能參考文獻:
    1. Treatment response to ivacaftor, which aims to improve CFTR-channel opening probability in cystic fibrosis patients with gating mutations, shows substantial variability in response, 28% of which can be explained by rs7512462 in SLC26A9. PMID: 28171547
    2. when SLC26A9 is coexpressed with F508del CFTR, its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9. PMID: 28360110
    3. SLC26A9 single nucleotide polymorphisms modify prenatal exocrine pancreatic damage in cystic fibrosis PMID: 25771386
    4. We have identified two SLC26A9 mutations decreasing Cl- channel transport in patients with a CF-like lung disease. PMID: 24272871
    5. SLC26A9 is an epithelial chloride/bicarbonate channel that can interact with the CF transmembrane regulator (CFTR), the protein mutated in CF PMID: 23670970
    6. Several SNPs in the 3' UTR of SLC26A9 (rs12031234, rs2282429, rs2282430)were associated with asthma in children with asthma. PMID: 22945630
    7. SLC26A9 polymorphisms lead to several function modifications (increased activity, decreased activity, altered protein expression), which could lead to a spectrum of pathophysiologies. PMID: 22544634
    8. Single nucleotide polymorphism in SLC26A9 gene is associated with cystic fibrosis. PMID: 22466613
    9. Report functional interaction between CFTR and SLC26A9 in polarized airway epithelial cells and in non-polarized HEK293 cells. PMID: 21809345
    10. the L683P mutation of SLC26A9 was found to reduce Cl(-) transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR ion transport activity PMID: 21439353
    11. The interactions between SLC26A9 and CFTR were studied, and an alternative hypothesis to their known interactions is presented. PMID: 20658517
    12. Functions as an anion conductance in the apical membranes of bronchial epithelium; contributes to transepithelial chloride currents under basal and cyclic AMP/protein kinase A-stimulated conditions. PMID: 19289574
    13. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport. PMID: 17120765
    14. SLC26A9 is a highly selective Cl(-) channel with minimal OH(-)/HCO(3)(-) permeability that is regulated by the WNK kinases. PMID: 17673510
    15. The transport properties of human SLC26A9 was studied to determine its functional and pharmacological characteristics. PMID: 18769029
    16. These results imply that Slc26-STAS domains may all interact with (R)CFTR but that the physiological outcome is specific to differing Slc26 proteins, allowing for dynamic and acute fine tuning of ion transport for various epithelia. PMID: 19643730

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC26A/SulP transporter (TC 2.A.53) family
  • 組織特異性:
    Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.
  • 數據庫鏈接:

    HGNC: 14469

    OMIM: 608481

    KEGG: hsa:115019

    STRING: 9606.ENSP00000341682

    UniGene: Hs.164073



主站蜘蛛池模板: 97se亚洲国产综合自在线观看 | 亚洲国产午夜精品理论片| 97一期涩涩97片久久久久久久| 亚洲 欧美 中文 日韩aⅴ| 欧美伊人色综合久久天天| 国产av一区二区三区日韩| 国产精品久免费的黄网站| 国产嘿嘿嘿视频在线观看| 成人啪精品视频网站午夜| 国模雨珍浓密毛大尺度150p| 强开小婷嫩苞又嫩又紧视频| 色情无码一区二区三区| 蜜臀性色av免费| 日韩欧美激情兽交| 国产精品成人3p一区二区三区 | 亚洲人成无码www久久久| 国产丝袜肉丝视频在线| 久久精品国产久精久精| 亚洲精华国产精华精华液网站| 西西人体大胆4444www| 亚洲一区二区制服在线| 欧美成人无码a区视频在线观看| 国产一区二区内射最近更新| 国产精品人人妻人人爽| 欧美中文亚洲v在线| 亚洲va在线∨a天堂va欧美va| 97香蕉碰碰人妻国产欧美| 国产人成网线在线播放va | 国产精品无码av在线一区| 欧美人与动性行为视频 | 亚洲欧美精品aaaaaa片| 亚洲综合小说另类图片五月天| 国产色诱视频在线播放网站| 亚洲一区二区三区av天堂| 一女被多男玩喷潮视频| 久久www香蕉免费人成| 综合精品欧美日韩国产在线| 免费无码又爽又刺激聊天app| 国产看真人毛片爱做a片| 久久久久国产精品人妻aⅴ天堂| 久久99er精品国产首页|