在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC26A9 Antibody, FITC conjugated

  • 中文名稱:
    SLC26A9兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA741974LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC26A9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC26A9
  • 別名:
    SLC26A9 antibody; Solute carrier family 26 member 9 antibody; Anion transporter/exchanger protein 9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier family 26 member 9 protein (551-660AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane.
  • 基因功能參考文獻:
    1. Treatment response to ivacaftor, which aims to improve CFTR-channel opening probability in cystic fibrosis patients with gating mutations, shows substantial variability in response, 28% of which can be explained by rs7512462 in SLC26A9. PMID: 28171547
    2. when SLC26A9 is coexpressed with F508del CFTR, its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9. PMID: 28360110
    3. SLC26A9 single nucleotide polymorphisms modify prenatal exocrine pancreatic damage in cystic fibrosis PMID: 25771386
    4. We have identified two SLC26A9 mutations decreasing Cl- channel transport in patients with a CF-like lung disease. PMID: 24272871
    5. SLC26A9 is an epithelial chloride/bicarbonate channel that can interact with the CF transmembrane regulator (CFTR), the protein mutated in CF PMID: 23670970
    6. Several SNPs in the 3' UTR of SLC26A9 (rs12031234, rs2282429, rs2282430)were associated with asthma in children with asthma. PMID: 22945630
    7. SLC26A9 polymorphisms lead to several function modifications (increased activity, decreased activity, altered protein expression), which could lead to a spectrum of pathophysiologies. PMID: 22544634
    8. Single nucleotide polymorphism in SLC26A9 gene is associated with cystic fibrosis. PMID: 22466613
    9. Report functional interaction between CFTR and SLC26A9 in polarized airway epithelial cells and in non-polarized HEK293 cells. PMID: 21809345
    10. the L683P mutation of SLC26A9 was found to reduce Cl(-) transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR ion transport activity PMID: 21439353
    11. The interactions between SLC26A9 and CFTR were studied, and an alternative hypothesis to their known interactions is presented. PMID: 20658517
    12. Functions as an anion conductance in the apical membranes of bronchial epithelium; contributes to transepithelial chloride currents under basal and cyclic AMP/protein kinase A-stimulated conditions. PMID: 19289574
    13. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport. PMID: 17120765
    14. SLC26A9 is a highly selective Cl(-) channel with minimal OH(-)/HCO(3)(-) permeability that is regulated by the WNK kinases. PMID: 17673510
    15. The transport properties of human SLC26A9 was studied to determine its functional and pharmacological characteristics. PMID: 18769029
    16. These results imply that Slc26-STAS domains may all interact with (R)CFTR but that the physiological outcome is specific to differing Slc26 proteins, allowing for dynamic and acute fine tuning of ion transport for various epithelia. PMID: 19643730

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC26A/SulP transporter (TC 2.A.53) family
  • 組織特異性:
    Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.
  • 數據庫鏈接:

    HGNC: 14469

    OMIM: 608481

    KEGG: hsa:115019

    STRING: 9606.ENSP00000341682

    UniGene: Hs.164073



主站蜘蛛池模板: 国产边打电话边被躁视频| 亚洲欧美v国产一区二区| 精品无码国产日韩制服丝袜| 中文字幕久久精品一区二区三区| 俄罗斯少妇性xxxx另类| 就去干成人网| 婷婷五月综合激情| 色偷一区国产精品| 国产精品无码2021在线观看| 欧美变态另类牲交| 国产精品无码一区二区三级| 中文字幕色av一区二区三区| 性色欲情网站iwww| 亚洲成a×人片在线观看| 亚洲大码熟女在线观看| 人与动人物xxxx毛片| 五月开心播播网| 动漫精品专区一区二区三区不卡 | 日本精品高清一区二区| 2020精品国产自在现线看| 中文字幕久久久久人妻中出| 无码专区丰满人妻斩六十路| 少妇人妻真实偷人精品视频| 奇米影视777四色狠狠| 国产精品高潮呻吟av久久| 国产无遮挡又黄又爽不要vip软件| 欧美午夜一区二区福利视频| 337人体做爰大胆视频| 婷婷俺也去俺也去官网| 偷拍农村老熟妇xxxxx7视频| 性xxxx18免费观看视频| 久久精品国产99国产精偷| 国产成人精品无码一区二区三区| 波多野结衣一区二区三区av免费| 一二三四在线视频社区3| 人妻丰满熟妇av无码区hd| 亚洲国产精品第一区二区三区 | 久久天天躁夜夜躁狠狠综合| 国产女人抽搐喷浆视频| 色插图午夜影院| 免费观看激色视频网站|