在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC26A9 Antibody, HRP conjugated

  • 中文名稱:
    SLC26A9兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA741974LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SLC26A9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SLC26A9
  • 別名:
    SLC26A9 antibody; Solute carrier family 26 member 9 antibody; Anion transporter/exchanger protein 9 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Solute carrier family 26 member 9 protein (551-660AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane.
  • 基因功能參考文獻:
    1. Treatment response to ivacaftor, which aims to improve CFTR-channel opening probability in cystic fibrosis patients with gating mutations, shows substantial variability in response, 28% of which can be explained by rs7512462 in SLC26A9. PMID: 28171547
    2. when SLC26A9 is coexpressed with F508del CFTR, its trafficking defect leads to a PDZ motif-sensitive intracellular retention of SLC26A9. PMID: 28360110
    3. SLC26A9 single nucleotide polymorphisms modify prenatal exocrine pancreatic damage in cystic fibrosis PMID: 25771386
    4. We have identified two SLC26A9 mutations decreasing Cl- channel transport in patients with a CF-like lung disease. PMID: 24272871
    5. SLC26A9 is an epithelial chloride/bicarbonate channel that can interact with the CF transmembrane regulator (CFTR), the protein mutated in CF PMID: 23670970
    6. Several SNPs in the 3' UTR of SLC26A9 (rs12031234, rs2282429, rs2282430)were associated with asthma in children with asthma. PMID: 22945630
    7. SLC26A9 polymorphisms lead to several function modifications (increased activity, decreased activity, altered protein expression), which could lead to a spectrum of pathophysiologies. PMID: 22544634
    8. Single nucleotide polymorphism in SLC26A9 gene is associated with cystic fibrosis. PMID: 22466613
    9. Report functional interaction between CFTR and SLC26A9 in polarized airway epithelial cells and in non-polarized HEK293 cells. PMID: 21809345
    10. the L683P mutation of SLC26A9 was found to reduce Cl(-) transport through SLC26A9 as well as the positive interaction exerted by SLC26A9 on CFTR ion transport activity PMID: 21439353
    11. The interactions between SLC26A9 and CFTR were studied, and an alternative hypothesis to their known interactions is presented. PMID: 20658517
    12. Functions as an anion conductance in the apical membranes of bronchial epithelium; contributes to transepithelial chloride currents under basal and cyclic AMP/protein kinase A-stimulated conditions. PMID: 19289574
    13. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport. PMID: 17120765
    14. SLC26A9 is a highly selective Cl(-) channel with minimal OH(-)/HCO(3)(-) permeability that is regulated by the WNK kinases. PMID: 17673510
    15. The transport properties of human SLC26A9 was studied to determine its functional and pharmacological characteristics. PMID: 18769029
    16. These results imply that Slc26-STAS domains may all interact with (R)CFTR but that the physiological outcome is specific to differing Slc26 proteins, allowing for dynamic and acute fine tuning of ion transport for various epithelia. PMID: 19643730

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    SLC26A/SulP transporter (TC 2.A.53) family
  • 組織特異性:
    Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.
  • 數據庫鏈接:

    HGNC: 14469

    OMIM: 608481

    KEGG: hsa:115019

    STRING: 9606.ENSP00000341682

    UniGene: Hs.164073



主站蜘蛛池模板: 产精品视频在线观看免费| 亚洲婷婷综合色香五月| 精品精品国产男人的天堂| 成年网站未满十八禁视频天堂 | 精品亚洲国产成人a片app| 四房播色综合久久婷婷| 少妇被粗大的猛烈进出动视频| 精品人妻无码一区二区三区蜜桃一| 亚洲日韩乱码中文无码蜜桃臀| 免费无码成人片| 亚洲 另类 在线 欧美 制服| 人人妻碰人人免费| 国产综合一区二区三区黄页秋霞| 成人区人妻精品一区二区三区 | 精品欧美аv高清免费视频| 欧美乱码卡一卡二卡三新区| 国产自产v一区二区三区c| 中文人妻av久久人妻18| 亚色九九九全国免费视频| 熟妇人妻无乱码中文字幕| 精品国产乱码久久久久久郑州公司| 婷婷开心激情综合五月天| 国产白嫩护士在线播放| 日韩亚洲国产主播在线不卡| 午夜dj在线观看免费视频| 丰满少妇作爱视频免费观看| 精品国产免费第一区二区三区| 精品国产在天天在线观看| 国产午夜福利在线观看视频| 色综合久久久久综合体桃花网| 久久不见久久见www免费| 色琪琪av中文字幕一区二区| 国产成人av一区二区三区| 狠狠做深爱婷婷久久综合一区 | 亚 洲 视 频 高 清 无 码| 国产成人精品福利网站| 久久婷婷人人澡人人爽人人喊| 人妻三级日本三级日本三级极| 手机在线看永久av片免费| 欧美性大战xxxxx久久久| 一本久久a久久免费精品不卡|