在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine/threonine-protein kinase Kist (UHMK1)

  • 中文名稱:
    人UHMK1重組蛋白
  • 貨號:
    CSB-YP840554HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人UHMK1重組蛋白
  • 貨號:
    CSB-EP840554HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人UHMK1重組蛋白
  • 貨號:
    CSB-EP840554HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人UHMK1重組蛋白
  • 貨號:
    CSB-BP840554HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人UHMK1重組蛋白
  • 貨號:
    CSB-MP840554HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    UHMK1
  • Uniprot No.:
  • 別名:
    DKFZp434C1613; FLJ23015; kinase interacting with leukemia-associated gene (stathmin); Kinase interacting with stathmin; KIS; KIS protein kinase; KIST; OTTHUMP00000029529; P-CIP2; Serine threonine protein kinase Kist; Serine/threonine-protein kinase Kist; U2AF homology motif (UHM) kinase 1; U2AF homology motif kinase 1; UHMK1; UHMK1_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-419
  • 氨基酸序列
    MAGSGCAWGA EPPRFLEAFG RLWQVQSRLG SGSSASVYRV RCCGNPGSPP GALKQFLPPG TTGAAASAAE YGFRKERAAL EQLQGHRNIV TLYGVFTIHF SPNVPSRCLL LELLDVSVSE LLLYSSHQGC SMWMIQHCAR DVLEALAFLH HEGYVHADLK PRNILWSAEN ECFKLIDFGL SFKEGNQDVK YIQTDGYRAP EAELQNCLAQ AGLQSDTECT SAVDLWSLGI ILLEMFSGMK LKHTVRSQEW KANSSAIIDH IFASKAVVNA AIPAYHLRDL IKSMLHDDPS RRIPAEMALC SPFFSIPFAP HIEDLVMLPT PVLRLLNVLD DDYLENEEEY EDVVEDVKEE CQKYGPVVSL LVPKENPGRG QVFVEYANAG DSKAAQKLLT GRMFDGKFVV ATFYPLSAYK RGYLYQTLL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.
  • 基因功能參考文獻:
    1. UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells. PMID: 29307747
    2. genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians. PMID: 27424934
    3. The contribution of UHMK1 gene in schizophrenia susceptibility, was explored. PMID: 21399567
    4. We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens. PMID: 12093740
    5. KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors. PMID: 12782393
    6. These results provide preliminary evidence that the UHMK1 gene increases susceptibility to schizophrenia. Further confirmation in adequately powered samples is needed. PMID: 16978587
    7. KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression PMID: 17726090
    8. Results show that KIS is a direct transcriptional target of FoxM1. PMID: 17984092
    9. Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia PMID: 18384876
    10. The association between UHMK1 and schizophrenia is confirmed. PMID: 18414510
    11. KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines. PMID: 19747464
    12. A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample. PMID: 18414510
    13. Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP. PMID: 16978587

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性:
    Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 19683

    OMIM: 608849

    KEGG: hsa:127933

    STRING: 9606.ENSP00000420270

    UniGene: Hs.127310



主站蜘蛛池模板: 日日婷婷夜日日天干| 久久精品人妻少妇一区二区三区 | 狠狠人妻久久久久久综合 | 亚洲国产成人精品久久久| 凹凸国产熟女精品视频| 在线亚洲综合欧美网站首页| 99热这里只有是精品2| 成人欧美一区二区三区| 精品人妻一区二区三区四区| 国产 高清 无码 在线播放| 色噜噜狠狠成人中文综合| 午夜福利三级理论电影| 国产 一二三四五六| 狠狠久久久久综合成人影院| 他掀开裙子把舌头伸进去添视频| 青青草大香焦在线综合视频 | 国产精品成人3p一区二区三区 | 伊人久久成综合久久影院| 久久婷婷五月综合中文字幕| 欧美亚洲国产片在线播放| 国产精品久久国产精品99 gif| 男女车车的车车网站w98免费| 国产精品白丝av网站| 国产乱码一区二区三区爽爽爽| 无码人妻一区二区三区在线| 男ji大巴进入女人的视频小说| 亚洲中文字幕不卡无码| 狠狠做五月深爱婷婷伊人| 午夜福利理论片在线观看播放| 亚洲国产精品无码久久一线| 波多野结av在线无码中文| 香蕉久久国产av一区二区| 五十老熟妇乱子伦免费观看| 午夜成人无码片在线观看影院| 久久青青草免费线频观| 国产日产亚洲系列最新| 久久精品国产9久久综合| 老湿机香蕉久久久久久| 久9视频这里只有精品| 极品粉嫩国产18尤物在线观看| 亚洲成av人片在www鸭子|