在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine/arginine-rich splicing factor 9 (SRSF9)

  • 中文名稱:
    Recombinant Human Serine/arginine-rich splicing factor 9 (SRSF9)
  • 貨號:
    CSB-EP618767HUc7
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    SRSF9
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    32.5 kDa
  • 表達區域:
    1-221aa
  • 氨基酸序列
    MSGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVRFEDPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRNGPPTRRSDFRVLVSGLPPSGSWQDLKDHMREAGDVCYADVQKDGVGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYIRVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPFRPY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.
  • 基因功能參考文獻:
    1. Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 and SRSF3 in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA. PMID: 28373129
    2. Report no correlation between expression of glucocorticoid receptor isoforms and SRp30c. PMID: 25665148
    3. Overexpression of SRSF9 and SRSF1 promote beta-catenin accumulation via the recruitment of beta-catenin mRNA and by enhancing its translation in an mTOR-dependent manner. PMID: 23592547
    4. Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness. PMID: 22205602
    5. these data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in bladder cancer. PMID: 22178073
    6. These results suggest that SRp30c can activate human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism: directly by stimulating splicing to late splice sites and indirectly by inhibiting competing early splice sites. PMID: 21697349
    7. SRp30c can function as a repressor of 3' splice site utilization and suggest that the SRp30c-CE9 interaction may contribute to the control of hnRNP A1 alternative splicing. PMID: 12024014
    8. SRp30c protein is an interacting protein of YB-1 PMID: 12604611
    9. Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. PMID: 12738786
    10. Results suggest that bombesin-induced expression of SRp30c affects gllucorticoid receptor (GR) pre-mRNA splicing, leading to increased GR beta expression and contributing to glucocorticoid resistance in PC cells. PMID: 17540466
    11. Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. PMID: 17548433
    12. SRp30c stimulates splicing to the downstream 5' splice site of Bcl-x(L), thereby attenuating the repressive effect of upstream U1 snRNP binding sit PMID: 18534987
    13. findings indicate the importance of arginine methylation for the subnuclear localization of SFRS9. PMID: 19557313

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.
  • 蛋白家族:
    Splicing factor SR family
  • 組織特異性:
    Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 10791

    OMIM: 601943

    KEGG: hsa:8683

    STRING: 9606.ENSP00000229390

    UniGene: Hs.706889



主站蜘蛛池模板: 亚洲精品白浆高清久久久久久 | 狠狠色综合久久丁香婷婷| 国产精品亚洲专区无码老司国| 久久一日本综合色鬼综合色| 国产精品区av| 狠狠97人人婷婷五月| 少妇人妻综合久久中文字幕| 免费人成网站在线观看不卡| 亚洲成在线aⅴ免费视频| 国产免费高清69式视频在线观看| 欧洲人妻丰满av无码久久不卡| 狠狠88综合久久久久综合网| 国产二级一片内射视频播放| 久久亚洲精品无码爱剪辑| 99国产欧美久久久精品| 日韩电影一区二区三区| 国内露脸中年夫妇交换| 狠狠色噜噜狠狠狠狠888奇禾| 体验区试看120秒啪啪免费| 深夜福利小视频在线观看| 国产精品秘入口18禁麻豆免会员| 久久久综合九色合综国产精品| 九九99无码精品视频在线观看| 人妻体验按摩到忍不住哀求继续| 无码国产69精品久久久久孕妇| 亚洲一区激情校园小说| 日韩成人无码v清免费| 国产精华av午夜在线| 免费人成自慰网站| 亚洲乱亚洲乱妇| 草裙社区精品视频三区免费看| 一本久道综合色婷婷五月| 日出水了特别黄的视频| 久久久亚洲精品无码| 午夜视频在线观看免费完整版| 国产疯狂伦交大片| 国产精品久久精品国产| av无码免费岛国动作片片段欣赏网| 成人无码av网站在线观看| 色悠久久久久综合网国产| 日本高清无卡码一区二区久久|