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  4. SRSF9 Antibody

SRSF9 Antibody

  • 中文名稱：
    SRSF9兔多克隆抗體
  • 貨號：
    CSB-PA00214A0Rb
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: SRSF9 antibody at 2µg/ml + Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SRSF9 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SRSF9
  • 別名：
    arginine/serine-rich 9 antibody; Pre mRNA splicing factor SRp30C antibody; Pre-mRNA-splicing factor SRp30C antibody; Serine/arginine-rich splicing factor 9 antibody; SFRS 9 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 9 antibody; splicing factor, arginine/serine-rich 9 antibody; splicing factor, arginine/serine-rich, 30-KD, C antibody; SR splicing factor 9 antibody; SRP30C antibody; SRSF9 antibody; SRSF9_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Serine/arginine-rich splicing factor 9 protein (1-221AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SRSF9 Antibody (CSB-PA00214A0Rb)，的標記方式是Non-conjugated。對于SRSF9 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA00214B0Rb SRSF9 Antibody, HRP conjugated ELISA
    FITC CSB-PA00214C0Rb SRSF9 Antibody, FITC conjugated
    Biotin CSB-PA00214D0Rb SRSF9 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.
  • 基因功能參考文獻：
    1. Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 and SRSF3 in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA. PMID: 28373129
    2. Report no correlation between expression of glucocorticoid receptor isoforms and SRp30c. PMID: 25665148
    3. Overexpression of SRSF9 and SRSF1 promote beta-catenin accumulation via the recruitment of beta-catenin mRNA and by enhancing its translation in an mTOR-dependent manner. PMID: 23592547
    4. Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness. PMID: 22205602
    5. these data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in bladder cancer. PMID: 22178073
    6. These results suggest that SRp30c can activate human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism: directly by stimulating splicing to late splice sites and indirectly by inhibiting competing early splice sites. PMID: 21697349
    7. SRp30c can function as a repressor of 3' splice site utilization and suggest that the SRp30c-CE9 interaction may contribute to the control of hnRNP A1 alternative splicing. PMID: 12024014
    8. SRp30c protein is an interacting protein of YB-1 PMID: 12604611
    9. Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. PMID: 12738786
    10. Results suggest that bombesin-induced expression of SRp30c affects gllucorticoid receptor (GR) pre-mRNA splicing, leading to increased GR beta expression and contributing to glucocorticoid resistance in PC cells. PMID: 17540466
    11. Study shows that PTB can function as an anti-repressor molecule to counteract the splicing inhibitory activity of SRp30c. PMID: 17548433
    12. SRp30c stimulates splicing to the downstream 5' splice site of Bcl-x(L), thereby attenuating the repressive effect of upstream U1 snRNP binding sit PMID: 18534987
    13. findings indicate the importance of arginine methylation for the subnuclear localization of SFRS9. PMID: 19557313

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  • 亞細胞定位：
    Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.
  • 蛋白家族：
    Splicing factor SR family
  • 組織特異性：
    Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 10791

    OMIM: 601943

    KEGG: hsa:8683

    STRING: 9606.ENSP00000229390

    UniGene: Hs.706889



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