在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human S-arrestin (SAG)

In Stock
  • 中文名稱:
    人SAG重組蛋白
  • 貨號:
    CSB-YP020669HU
  • 規(guī)格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP020669HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) SAG.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP020669HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) SAG.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    SAG
  • Uniprot No.:
  • 別名:
    48 kDa protein; Arrestin 1; Arrestin; ARRS_HUMAN; Retinal S antigen (48 KDa protein); Retinal S-antigen; Rod photoreceptor arrestin; RP47; S antigen; S antigen retina and pineal gland (arrestin); S arrestin; S-AG; S-arrestin; SAG
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    47.1kDa
  • 表達(dá)區(qū)域:
    1-405aa
  • 氨基酸序列
    MAASGKTSKSEPNHVIFKKISRDKSVTIYLGNRDYIDHVSQVQPVDGVVLVDPDLVKGKKVYVTLTCAFRYGQEDIDVIGLTFRRDLYFSRVQVYPPVGAASTPTKLQESLLKKLGSNTYPFLLTFPDYLPCSVMLQPAPQDSGKSCGVDFEVKAFATDSTDAEEDKIPKKSSVRLLIRKVQHAPLEMGPQPRAEAAWQFFMSDKPLHLAVSLNKEIYFHGEPIPVTVTVTNNTEKTVKKIKAFVEQVANVVLYSSDYYVKPVAMEEAQEKVPPNSTLTKTLTLLPLLANNRERRGIALDGKIKHEDTNLASSTIIKEGIDRTVLGILVSYQIKVKLTVSGFLGELTSSEVATEVPFRLMHPQPEDPAKESYQDANLVFEEFARHNLKDAGEAEEGKRDKNDVDE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
  • 基因功能參考文獻(xiàn):
    1. This is the first dominant-acting mutation identified in SAG, a founder mutation possibly originating in Mexico several centuries ago. The phenotype is clearly adRP and is distinct from the previously reported phenotypes of recessive null mutations, that is, Oguchi disease and recessive RP. PMID: 28549094
    2. Macular dysfunction can occur in Oguchi disease with the 1147delA mutation in the SAG gene. PMID: 21447990
    3. Based on their observed affinity for arrestin-1, P-opsin and inactive P-Rh very likely affect the physiological monomer-dimer-tetramer equilibrium of arrestin-1, and should therefore be taken into account when modeling photoreceptor function. PMID: 23277586
    4. Compound heterozygosity of a nonsense R193X mutation and a heterozygous deletion of 3,224 bp encompassing exon 2 in the SAG gene is the cause of Oguchi's disease in a Chinese family. PMID: 22419846
    5. the arrestin 1147delA, which has been known as a frequent cause of Oguchi disease, also may be related to the pathogenesis of autosomal recessive RP. PMID: 21922265
    6. We describe a case of Oguchi disease with unusual findings caused by a putative heterozygous mutation in the SAG gene. PMID: 21987685
    7. maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association PMID: 21288033
    8. Rhodopsin-arrestin complexes alter the morphology of endosomal compartments and severely damage receptor-mediated endocytic functions in retinitis pigmentosa. PMID: 15232620
    9. The existence of 2 novel mutations of the arrestin gene in 2 unrelated Japanese patients strongly supports the previous data that arrestin gene mutations are associated with Oguchi's disease PMID: 15234147
    10. Mutation 926delA of the SAG gene is the main cause of Oguchi disease in Japanese. This mutation appears to have been inherited from a single founder. PMID: 15295660
    11. The tetramer form of arrestin increases the arrestin-binding capacity of microtubules while readily dissociating to supply active monomer when it is needed to quench rhodopsin signaling. PMID: 17332750
    12. ARRESTIN binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences. PMID: 18413662
    13. S-Ag specific T cells are present in certain active Behcet's disease patients, and most of them are activated memory CD4(+) T cells. PMID: 18685727

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Night blindness, congenital stationary, Oguchi type 1 (CSNBO1); Retinitis pigmentosa 47 (RP47)
  • 亞細(xì)胞定位:
    Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    Arrestin family
  • 組織特異性:
    Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10521

    OMIM: 181031

    KEGG: hsa:6295

    STRING: 9606.ENSP00000386444

    UniGene: Hs.32721



主站蜘蛛池模板: 亚洲高清乱码午夜电影网制服| 亚洲ⅴ国产v天堂a无码二区| 国产成人免费爽爽爽视频| 最新高清中文字幕免费mv| 人人妻人人爽人人澡av| 成人无码一区二区三区网站| 男人用嘴添女人下身免费视频| 亚洲成a人片在线观看www| 7m精品福利视频导航| 亚洲色老汉av无码专区最| 米奇影院888奇米色99在线| 精品无人码麻豆乱码1区2区| 亚洲熟妇av日韩熟妇在线| 欧美人与动交视频在线观看| 国产精品va在线观看h| 久久亚洲国产成人精品无码区| 十八18禁国产精品www| 久久久精品欧美一区二区免费 | av小次郎收藏| 无码av大香线蕉伊人久久| 人妻夜夜爽天天爽三区麻豆av网站 | 久久久久成人精品无码| 亚洲三区在线观看内射后入 | 亚洲中文字幕无码卡通动漫野外| 国产剧情无码播放在线看 | 一本精品中文字幕在线| 99er国产这里只有精品视频免费| 337p亚洲日本中国大胆69| 亚洲风影视传媒有限公司辽宁| 国产美女在线精品免费观看网址| 免费特级毛片| 亚洲综合色区另类小说 | 亚洲精品久久夜色撩人男男小说| 日本一本二本三区免费| 国产天堂久久天堂av色综合| 午夜内射中出视频| 两女女百合互慰av赤裸无遮挡| 国语精品一区二区三区| 亚洲精品卡2卡3卡4卡5卡区| 女人与公拘交酡全过程| 久久久久久久性潮|