在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SAG Antibody, FITC conjugated

  • 中文名稱:
    SAG兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA020669YC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SAG Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SAG
  • 別名:
    48 kDa protein antibody; Arrestin 1 antibody; Arrestin antibody; ARRS_HUMAN antibody; Retinal S antigen (48 KDa protein) antibody; Retinal S-antigen antibody; Rod photoreceptor arrestin antibody; RP47 antibody; S antigen antibody; S antigen retina and pineal gland (arrestin) antibody; S arrestin antibody; S-AG antibody; S-arrestin antibody; SAG antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human S-arrestin protein (1-405AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells.
  • 基因功能參考文獻:
    1. This is the first dominant-acting mutation identified in SAG, a founder mutation possibly originating in Mexico several centuries ago. The phenotype is clearly adRP and is distinct from the previously reported phenotypes of recessive null mutations, that is, Oguchi disease and recessive RP. PMID: 28549094
    2. Macular dysfunction can occur in Oguchi disease with the 1147delA mutation in the SAG gene. PMID: 21447990
    3. Based on their observed affinity for arrestin-1, P-opsin and inactive P-Rh very likely affect the physiological monomer-dimer-tetramer equilibrium of arrestin-1, and should therefore be taken into account when modeling photoreceptor function. PMID: 23277586
    4. Compound heterozygosity of a nonsense R193X mutation and a heterozygous deletion of 3,224 bp encompassing exon 2 in the SAG gene is the cause of Oguchi's disease in a Chinese family. PMID: 22419846
    5. the arrestin 1147delA, which has been known as a frequent cause of Oguchi disease, also may be related to the pathogenesis of autosomal recessive RP. PMID: 21922265
    6. We describe a case of Oguchi disease with unusual findings caused by a putative heterozygous mutation in the SAG gene. PMID: 21987685
    7. maintenance of low levels of the active monomer is the biological role of arrestin-1 self-association PMID: 21288033
    8. Rhodopsin-arrestin complexes alter the morphology of endosomal compartments and severely damage receptor-mediated endocytic functions in retinitis pigmentosa. PMID: 15232620
    9. The existence of 2 novel mutations of the arrestin gene in 2 unrelated Japanese patients strongly supports the previous data that arrestin gene mutations are associated with Oguchi's disease PMID: 15234147
    10. Mutation 926delA of the SAG gene is the main cause of Oguchi disease in Japanese. This mutation appears to have been inherited from a single founder. PMID: 15295660
    11. The tetramer form of arrestin increases the arrestin-binding capacity of microtubules while readily dissociating to supply active monomer when it is needed to quench rhodopsin signaling. PMID: 17332750
    12. ARRESTIN binds to different phosphorylated regions of the thyrotropin-releasing hormone receptor with distinct functional consequences. PMID: 18413662
    13. S-Ag specific T cells are present in certain active Behcet's disease patients, and most of them are activated memory CD4(+) T cells. PMID: 18685727

    顯示更多

    收起更多

  • 相關疾病:
    Night blindness, congenital stationary, Oguchi type 1 (CSNBO1); Retinitis pigmentosa 47 (RP47)
  • 亞細胞定位:
    Cell projection, cilium, photoreceptor outer segment. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    Arrestin family
  • 組織特異性:
    Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).
  • 數據庫鏈接:

    HGNC: 10521

    OMIM: 181031

    KEGG: hsa:6295

    STRING: 9606.ENSP00000386444

    UniGene: Hs.32721



主站蜘蛛池模板: 国产xxx视频在线观看软件| 国产成a人亚洲精品无码久久网| 西西人体www大胆高清视频| 中文字幕无码日韩专区免费| 99精品视频一区在线观看| 女人被狂躁高潮啊的视频在线看| 国产精品久久久久久久久久红粉| 国自产拍偷拍精品啪啪一区二区| 亚洲精品国产精品制服丝袜| 日韩国产亚洲一区二区三区| 无码毛片一区二区本码视频| 免费无码毛片一区二区三区a片| 中文字幕日本人妻久久久免费| 国产成人精品福利一区二区三区| 国产亚洲999精品aa片在线爽| 中文字幕欧美亚州视频免费| 国产精品人成视频免费999| 十八岁污网站在线观看| 天天爱天天做久久狠狠做| 亚洲国产精品无码中文字2022| 大地资源中文第三页| 国产一区二区三区四区五区加勒比| 丰满少妇高潮惨叫久久久一| 免费国产高清毛不卡片基地| 日本少妇自慰免费完整版| 国产女主播喷水视频在线观看| 日产精品一区2区卡四卡二卡 | 亚洲成a∧人片在线播放无码 | 五月丁香六月综合缴清无码 | 精品香蕉久久久午夜福利| 午夜福利视频一区二区手机免费看| 欧美人与性动交g欧美精器| 欧美日韩一区二区三区视频播放| 国内揄拍国内精品对白| 久久精品人人做人人爱爱漫画 | 成人无码av网站在线观看| 18禁超污无遮挡无码免费游戏| 国产精品成人免费一区久久羞羞| 卡1卡2卡3精品接入口| 97久久草草超级碰碰碰| 国产成人精品123区免费视频|