在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Regulator of microtubule dynamics protein 3 (RMDN3)

  • 中文名稱:
    人RMDN3重組蛋白
  • 貨號:
    CSB-EP836307HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    RMDN3
  • Uniprot No.:
  • 別名:
    RMDN3; FAM82A2; FAM82C; PTPIP51; hucep-10; UNQ3122/PRO10274; Regulator of microtubule dynamics protein 3; RMD-3; hRMD-3; Cerebral protein 10; Protein FAM82A2; Protein FAM82C; Protein tyrosine phosphatase-interacting protein 51; TCPTP-interacting protein 51
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    56.1kDa
  • 表達區域:
    1-470aa
  • 氨基酸序列
    MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDFLWRLARAYSDMCELTEEVSEKKSYALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
  • 基因功能參考文獻:
    1. Study shows that the VAPB-PTPIP51 tethers regulate autophagy and demonstrates that overexpression of VAPB or PTPIP51 to tighten endoplasmic reticulum-mitochondria contacts impairs, whereas small interfering RNA-mediated loss of VAPB or PTPIP51 to loosen contacts stimulates, autophagosome formation. PMID: 28132811
    2. the latest findings concerning PTPIP51 protein function, regulation and protein complex formation with regard to the involved signaling pathways and subcellular compartments (review) PMID: 27734150
    3. High PTPIP51 expression is associated with glioblastoma. PMID: 25862004
    4. PTPIP51 is regulated by its phosphorylation status combined with a thereby induced subcellular redistribution. PMID: 24501773
    5. The presented data confirms a tyrosine phosphorylation-dependent interaction of PTPIP51 with 14-3-3beta and Raf-1 in vivo and a tyrosine-dependent interaction profile with DAGKalpha and PKA. PMID: 22544307
    6. In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B. PMID: 21972092
    7. PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia. PMID: 21513978
    8. PTPIP51 expression was restricted to myeloid precursor cells undergoing differentiation. In blood cells therefore, PTPIP51 expression is restricted to differentiating and mature neutrophil granulocytes. PMID: 20627780
    9. PTPIP51 might be involved in the regulation of cellular processes associated with differentiation, movement, or cytoskeletal organization PMID: 15609043
    10. PTPIP51 is a mitochondrial protein with apoptosis-inducing function and that the N-terminal TM domain is required for both the correct targeting of the protein to mitochondria and its apoptotic functions. PMID: 16820967
    11. PTPIP51 and PTP1B, play a role in differentiation and apoptosis of the cytotrophoblast and syncytiotrophoblast, respectively. Moreover, PTPIP51 may also serve as a cellular signaling partner in angiogenesis and vascular remodeling. PMID: 18854601
    12. FAM82A2 is expressed in keratinocyte carcinoma and their surrounding stroma. PMID: 19012732
    13. The results clearly point toward a strong association between PTPIP51 expression and differentiation in human muscle cells. PMID: 19124842
    14. The promoter methylation status of PTPIP51 seems to influence the expression of PTPIP51, which was seen as elevated in the prostate carcinoma. PMID: 19691131

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族:
    RMDN family
  • 組織特異性:
    Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high
  • 數據庫鏈接:

    HGNC: 25550

    OMIM: 611873

    KEGG: hsa:55177

    STRING: 9606.ENSP00000260385

    UniGene: Hs.511067



主站蜘蛛池模板: 亚洲女女女同性video| 中文人妻熟妇乱又伦精品| 99视频有精品视频高清| 欧美成人免费全部观看| 丰满多毛少妇做爰视频爽爽和| 日本熟妇厨房bbw| 国产精品毛片大码女人| 精品国产欧美一区二区| 日韩无码专区| 国产亚洲产品影视在线产品| 2021国产精品香蕉在线观看| 天干天干啦夜天干天天爽| 熟妇无码乱子成人精品| 亚洲久热无码av中文字幕| 中文字日产幕乱五区| 久久99青青精品免费观看| 99久久国产综合精品1| 日韩亚洲欧美中文高清在线| 欧美日韩午夜群交多人轮换| 兔费看少妇性l交大片免费| 夜色福利院在线观看免费| 亚洲成av人在线观看天堂无码| 情侣激情18内射骚话国产| 丰满人妻在公车被猛烈进入电影| 成人h动漫精品一区二区无码| 欧美v亚洲v日韩v最新在线| 伊人久久大香线蕉av最新| av无码久久久久不卡网站下载| 午夜福利92国语| 国产日韩精品中文字无码| 国产亚洲精品久久久久小| 一区二区狠狠色丁香久久婷婷| 人人妻人人爽人人爽| 丰满人妻一区二区三区视频53| 久久中文字幕人妻丝袜| 欲香欲色天天综合久久| 免费观看又色又爽又湿的软件| 乱人伦人妻精品一区二区| 国产精成人品| 国产精品亚洲专区无码老司国| 熟妇的奶头又大又粗视频|