在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Rabphilin-3A (RPH3A)

  • 中文名稱:
    人RPH3A重組蛋白
  • 貨號:
    CSB-YP896693HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RPH3A重組蛋白
  • 貨號:
    CSB-EP896693HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RPH3A重組蛋白
  • 貨號:
    CSB-EP896693HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RPH3A重組蛋白
  • 貨號:
    CSB-BP896693HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RPH3A重組蛋白
  • 貨號:
    CSB-MP896693HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RPH3A
  • Uniprot No.:
  • 別名:
    Exophilin 1; Exophilin-1; Exophilin1; KIAA0985; Rabphilin 3A homolog; Rabphilin-3A; Rabphilin3A; RP3A; RP3A_HUMAN; Rph 3a; Rph3a
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-694
  • 氨基酸序列
    MTDTVFSNSS NRWMYPSDRP LQSNDKEQLQ AGWSVHPGGQ PDRQRKQEEL TDEEKEIINR VIARAEKMEE MEQERIGRLV DRLENMRKNV AGDGVNRCIL CGEQLGMLGS ACVVCEDCKK NVCTKCGVET NNRLHSVWLC KICIEQREVW KRSGAWFFKG FPKQVLPQPM PIKKTKPQQP VSEPAAPEQP APEPKHPARA PARGDSEDRR GPGQKTGPDP ASAPGRGNYG PPVRRASEAR MSSSSRDSES WDHSGGAGDS SRSPAGLRRA NSVQASRPAP GSVQSPAPPQ PGQPGTPGGS RPGPGPAGRF PDQKPEVAPS DPGTTAPPRE ERTGGVGGYP AVGAREDRMS HPSGPYSQAS AAAPQPAAAR QPPPPEEEEE EANSYDSDEA TTLGALEFSL LYDQDNSSLQ CTIIKAKGLK PMDSNGLADP YVKLHLLPGA SKSNKLRTKT LRNTRNPIWN ETLVYHGITD EDMQRKTLRI SVCDEDKFGH NEFIGETRFS LKKLKPNQRK NFNICLERVI PMKRAGTTGS ARGMALYEEE QVERVGDIEE RGKILVSLMY STQQGGLIVG IIRCVHLAAM DANGYSDPFV KLWLKPDMGK KAKHKTQIKK KTLNPEFNEE FFYDIKHSDL AKKSLDISVW DYDIGKSNDY IGGCQLGISA KGERLKHWYE CLKNKDKKIE RWHQLQNENH VSSD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays an essential role in docking and fusion steps of regulated exocytosis. At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP-dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release. In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone.
  • 基因功能參考文獻:
    1. Findings indicate that Rph3A activity is linked to the aberrant synaptic localization of GluN2A-expressing NMDARs characterizing levodopa-induced dyskinesias; suggest that Rph3A/GluN2A complex could represent an innovative therapeutic target for those pathological conditions where NMDAR composition is significantly altered. PMID: 28823933
    2. Rabphilin-3A is a major autoantigen in Lymphocytic infundibulo-neurohypophysitis (LINH). Autoantibodies to rabphilin-3A may serve as biomarker for the diagnosis of LINH and be useful for the differential diagnosis of Central diabetes insipidus. PMID: 25919460
    3. rabphilin 3A loss correlated with dementia severity, cholinergic deafferentation, and increased beta-amyloid concentrations PMID: 24200817
    4. Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. PMID: 24302762
    5. Rabphilin-3A and Rab3A are present in normal mouse, rat, and human kidneys, with an exclusively glomerular expression and a comma-like pattern of positivity along the glomerular capillary wall, suggestive for podocyte staining. PMID: 12937130
    6. Since rab3a participates in the docking and fusion of synaptic vesicles, and rabsa binding to alpha-synuclein is increased in Lewy body disease (LBD), it can be suggested that exocytosis of neurotransmitters may be impaired in LBD. PMID: 15207266
    7. We found a reduction in rabphilin 3a, a protein involved in vesicle docking and recycling, in Huntington disease[HD] brains of grade III and IV. A deficient pre-synaptic transmitter release may underlie some symptoms of HD. PMID: 17877635

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane. Membrane; Peripheral membrane protein.
  • 數據庫鏈接:

    HGNC: 17056

    OMIM: 612159

    KEGG: hsa:22895

    STRING: 9606.ENSP00000374036

    UniGene: Hs.21239



主站蜘蛛池模板: 免费三级网站| 国产亚洲精品久久久999蜜臀| 99热在线精品免费全部my| 欧美性猛交aaaa片黑人| 久久久久人妻一区精品色欧美 | 国产乱人伦av在线a更新| 亚洲aⅴ天堂av天堂无码app| 国产爆乳成av人在线播放| 色婷婷综合激情综在线播放| 国产高清亚洲精品视bt天堂频| 女人与牲口性恔配视频免费| 国产福利免费视频不卡| 免费久久99精品国产自在现线| 99久久无色码中文字幕| 欧美丰满大乳高跟鞋| 少妇人妻在线视频| 扒开双腿吃奶呻吟做受视频| 正在播放的国产a一片| 国产成人无码av大片大片在线观看 | 一区二区伊人久久大杳蕉| 日本xxxx片免费观看| 精品熟女少妇av免费观看| 精品人妻无码一区二区三区| 国产福利萌白酱精品一区| 国产在热线精品视频| 色偷偷88888欧美精品久久久| 中文字幕乱码人在线视频1区| 中文字幕av无码免费久久| 久久99精品久久只有精品| 亚洲国产精品一区第二页| 宅男午夜成年影视在线观看| 日韩少妇人妻vs中文字幕| 亚洲日本va中文字幕| 亚洲午夜无码极品久久| 天堂av无码av在线a√| 美女视频黄频a免费| 在线看片免费人成视频福利 | 无码一区二区| 偷看农村妇女牲交| 无码啪啪熟妇人妻区| 日本va欧美va欧美va精品 |